Results 81 to 90 of about 301,268 (301)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Root mean square error.

, 2016
The root mean squared error (RMSE) distribution of diameter (d) and accumulated volume (Vac) for both training (black line) and validation (grey line) data sets, considering five hundred iterations for Artificial Neural Network (NN), Random Forest (RF ...
Eric Bastos Görgens (3169674), Matheus Henrique Nunes (3169671)   +1 more
core   +1 more source

Research on Parameter Inversion of Coal Mining Subsidence Prediction Model Based on Improved Whale Optimization Algorithm

Energies
Rapid coal mining results in a series of mining subsidence damages. Predicting surface movement and deformation accurately is essential to reducing mining damage.
Qingbiao Guo, Boqing Qiao, Yingming Yang, Junting Guo   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Comparison of errors generated by different similarity selection thresholds under the same experimental conditions (mean absolute error and root mean square error on MovieLens with selected users).

, 2022
Comparison of errors generated by different similarity selection thresholds under the same experimental conditions (mean absolute error and root mean square error on MovieLens with selected users).
Zhong Huang (358974), Jun Ai (519264), Fengyu Zhao (1781143), Zhan Su (264040), Lihui Shang (13170630), Xuanxiong Zhang (1976809)   +5 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Averaged root mean square error in synergy tasks (mean ± SE).

, 2019
Root mean square error (RMSE) by task-instructed finger(s) as a function of task-required force levels are plotted for IMRL synergy task (top panel) and I+M+R+L synergy task (bottom panel) respectively.
Elias Youssef (8138301), Sasha Reschechtko (8138295), Wei Zhang (405), Cynthia Benson (8138298), Barry Hahn (3705823)   +4 more
core   +1 more source

Root mean square error (RMSE) and mean absolute error (MAE) values of cross-validation for the different sets of inverse distance weighting parameters.

, 2023
Root mean square error (RMSE) and mean absolute error (MAE) values of cross-validation for the different sets of inverse distance weighting parameters.
Ismael H. Silveira (14123977), Taísa Rodrigues Cortes (14636533), Michelle L. Bell (16401), Washington Leite Junger (6588755)   +3 more
core   +1 more source