Results 61 to 70 of about 84,444 (264)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Machine Learning and Shapley Additive Explanations Value Integration for Predicting the Prognostic of Anti-N-Methyl-D-Aspartate Receptor Encephalitis: Model Development and Evaluation Study

JMIR Medical Informatics
BackgroundAnti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a rare disease with no accurate prognostic tools to predict the prognosis of patients. ObjectiveThis study aims to develop an interpretable machine learning model using real-
Jia Wang, Haotian Wu, Han Cai, YingXiang Wang, Jian Gu   +4 more
doaj   +1 more source

A fixed count sampling estimator of stem density based on a survival function

Journal of Forest Science, 2015
In fixed count sampling (FCS) a fixed number (k) of observations is made at n randomly selected sample locations. For estimation of stem density, the distance from a random sample location to the k nearest trees was measured.
S. Magnussen
doaj   +1 more source

Foveation-based content adaptive root mean squared error for video quality assessment

Multimedia Tools and Applications, 2017
When the video is compressed and transmitted over heterogeneous networks, it is necessary to ensure the satisfying quality for the end user. Since human observers are the end users of video applications, it is very important that the human visual system (HVS) characteristics are taken into account during the video quality evaluation.
Mario Vranjes, Snjezana Rimac-Drlje, Denis Vranjes   +2 more
openaire   +3 more sources

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

A New Method for Least-Squares and Minimax Group-Delay Error Design of Allpass Variable Fractional-Delay Digital Filters

EURASIP Journal on Advances in Signal Processing, 2010
A double-loop iterative method is proposed to design allpass variable fractional-delay (VFD) digital filters basing on the minimization of root-mean-squared group-delay error. In the inner loop, an iterative quadratic optimization is proposed to replace
Pei Soo-Chang, Shyu Jong-Jy, Chan Cheng-Han   +2 more
doaj  

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

MS-YieldStackNet: multi-source data fusion for wheat yield estimation using a stacked ensemble neural network [PDF]

PeerJ Computer Science
Accurate crop yield prediction is vital for ensuring food security and informing agricultural policy, particularly in wheat-dependent regions like Pakistan where manual estimation methods are labor-intensive and imprecise.
Waqas Ali, Zeeshan Ramzan, Muhammad Shahbaz, Qamar Ul Zaman Bhutta, Muhammad Talha, Mohammed J. AlGhamdi   +5 more
doaj   +2 more sources

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source