Results 291 to 300 of about 1,228,579 (380)

Changes in Protein Expression of Renal Drug Transporters and Drug‐Metabolizing Enzymes in Autosomal Dominant Polycystic Kidney Disease Patients

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease and leads to bilateral kidney enlargement and progressive loss of renal function, often over decades. Comorbidities include hypertension, flank pain, and bacterial infections. The condition often necessitates prolonged multidrug therapy.
Annika C. Tillmann   +6 more
wiley   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu   +21 more
wiley   +1 more source

TNF-<i>α</i> and RANKL facilitates the development of orthodontically-induced inflammatory root resorption

open access: gold, 2013
Tadashi Kojima   +6 more
openalex   +2 more sources

Microbiome‐Informed Dosing: Exploring Gut Microbial Communities Impact on Mycophenolate Enterohepatic Circulation and Therapeutic Target Achievement

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Pharmacomicrobiomics is an emerging field due to important microbiome effects on pharmacokinetics and clinical outcomes. However, the application of this knowledge remains limited. Mycophenolic acid (MPA) is the primary active metabolite of the immunosuppressant, mycophenolate mofetil (MMF).
Abdelrahman Saqr   +4 more
wiley   +1 more source

Think highly of immunoglobulin G4‐related chronic rhinosinusitis as a clinical entity in immunoglobulin G4‐related disease

open access: yesEye &ENT Research, EarlyView.
Abstract IgG4‐related chronic rhinosinusitis (IgG4‐related CRS) is gaining recognition among various specialized physicians. As a systemic disease involving multiple organs, IgG4‐related CRS is still not widely recognized as an independent clinical entity. Given the complexity of diagnosing autoimmune‐related multisystem diseases, early recognition and
Lianqi Wan   +3 more
wiley   +1 more source

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