Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Author Correction: Screening for or diagnosing medial meniscal root injury using peripheral medial joint space width ratio in plain radiographs [PDF]
Pasin Asawatreratanakul +3 more
openalex +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Network Localization of Fatigue in Multiple Sclerosis
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo +12 more
wiley +1 more source
Microbial leakage and apical inflammatory response in dog's teeth after root canal filling with different sealers, post space preparation and exposure to the oral environment [PDF]
Maximiliano Schünke Gomes +5 more
openalex +1 more source
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah +7 more
wiley +1 more source
Evaluation of the accuracy of direct digital impressions versus conventional silicone impressions for post-and-core with different root space diameters: a preliminary study in vitro. [PDF]
Shen J, Chen S, Chen R, Zheng Z, Lin J.
europepmc +1 more source
On to the continuity of the map square root of nonnegative isomorphisms in Hilbert spaces [PDF]
Jeovanny de Jesus Muentes Acevedo
openalex +1 more source
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo +9 more
wiley +1 more source
Differences in autotoxic substances and microbial community in the root space of <i>Panax notoginseng</i> coinducing the occurrence of root rot. [PDF]
Chen J +7 more
europepmc +1 more source

