Results 111 to 120 of about 9,573,537 (299)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Root Capital’s Expected Impact Rating [PDF]

, 2019
The purpose of this document is to provide more detail on the Expected Impact Rating that Root Capital developed to evaluate the expected impact of each loan relative to the net cost of that loan to Root ...
Root Capital
core   +1 more source

Respon Pertumbuhan dan Hasil Tanaman Selada Krop (Lactuca sativa var. capitata) terhadap Durasi Penggunaan Aerator dan Konsentrasi Pupuk Gandasil D pada Hidroponik Sistem Rakit Apung

Plantropica: Journal of Agricultural Science
Selada krop merupakan jenis selada yang pertumbuhannya seperti kubis dan dapat dibudidayakan di dataran menengah hingga tinggi. Produksi selada krop akan berpotensi menurun akibat penurunan luas lahan pertanian.
Maria Ivana Mariani Saputri, Nurul Aini
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Studying Morphological Characteristics of Seminal and Adventitious Root Systems of Durum and Bread Wheat Cultivars [PDF]

Ikufīziyuluzhī-i Giyāhān-i Zirā̒ī, 2016
To study the root structure  and its morphological characteristics of winter and durum wheat cultivars, an experiment was carried out based on randomized completely design with four replications at faculty of Agriculture, Ilam University during 2013-2014.
Rahim Naseri, Mehrshad Barari, Mohammad Javad Zarea, Kazem Khavazi, Zahra Tahmasebi   +4 more
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Vegetative growth of grain sorghum in response to phosphorus nutrition

Scientia Agricola, 2002
Morphological variables such as phytomass, plant height, leaf area, number of leaves, have been used to express the influence of mineral nutrients on plant growth patterns, since the vegetative development responds, in general, favorably to fertilizer ...
Rafael Camacho, Eurípedes Malavolta, José Guerrero-Alves, Tomás Camacho   +3 more
doaj