Results 111 to 120 of about 152,384 (269)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

SOIL COMPACTION IN AGROFORESTRY SYSTEMS CAN AFFECT THE EARLY STAGE GROWTH OF FARM TREES LIKE VACHELLIA NILOTICA (L.) P.J.H. HURTER & MABB

FUUAST Journal of Biology, 2019
Use of heavy machinery in agroforestry systems for intensive cropping is resulting in soil and subsoil compaction. The soil compaction is a process that results in the reduction of pore spaces between soil particles and increase in the soil bulk density.
MUDDASSAR HUSSAIN, MUHAMMAD FARRAKH NAWAZ, MUHAMMAD ASIF, IRFAN AHMAD, SADAF GUL, FAIZ RASOOL, GHULAM YASIN   +6 more
doaj  

Banana root and soil health project - Australia [PDF]

, 2005
The banana plant forms an adventitious root system that is dependent on soil physical, chemical and biological properties to function efficiently. A pot experiment demonstrated that increasing soil compaction was able to significantly reduce the weight ...
Smith, Linda, Badcock, K., Rasiah, V., Moody, P., Lindsay, Stewart J., Gulino, L., Cobon, Jennifer A., Pattison, Anthony B., Armour, J.   +8 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Relationship between root characteristics and saturated hydraulic conductivity in a grassed clayey soil

Soil saturated hydraulic conductivity plays a crucial role in the fields of hydrology, geotechnical and geological engineering. This study investigated the relationship between root characteristics and soil saturated hydraulic conductivity in a grassed ...
Cui, Ling Xin, So, Pui San, Li, Cong Ying, Cheng, Qing, Tian, Ben Gang, Tang, Chao Sheng   +5 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Growth and flowering response of cut chrysanthemums grown in restricted root conditions [PDF]

, 2014
Rooted cuttings of chrysanthemum (Chysanthemum morifolium cv. Reagan White) were grown in seedling trays of three differing volumes (34, 73, and 140 ml) and containing three different substrates (coconut peat, burnt rice husk, and coconut peat:burnt rice
Taweesak, Viyachai, Abdullah, Thohirah Lee, Hassan, Siti Aishah, Wan Yusof, Wan Abdullah, Kamarulzaman, Nitty Hirawaty   +4 more
core  

Database for the article "Acclimation of fine root systems to soil warming: comparison of an experimental setup and a natural soil temperature gradient", published in Ecosystems

, 2018
<p>The database contains measurements of fine root biomass, absorptive fine root biomass, absorptive root morphology (diameter, specific root length, specific root area, root tissue density, root tip length, root tip weight and branching per length
Kaarin Parts, Ivika Ostonen
core   +1 more source