Results 81 to 90 of about 596,386 (281)
The learning portfolio in higher education: an integrative review [PDF]
, 2018 The learning portfolio is often lauded as a powerful pedagogical tool, and consequently, is rapidly becoming a central feature of contemporary education.
Brown, Mark +2 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Imagining 'environment' in sustainable development [PDF]
, 2010 The paper presents an argument for a broader and more complex definition of environment than that currently offered in sustainable development discourse and practice.
Farrelly, Trisia Angela
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
From Local Crafts to Market Niches: The Marketing Potential of Artisanal Foods in Ukraine
FoodsThis study explores the marketing potential of artisanal agri-food products in Ukraine by examining their structural, regional, and consumer dimensions.
Yuriy Danko +6 more
doaj +1 more source
On Modern Science, Human Cognition, and Cultural Diversity [PDF]
, 2000 The development of modern science has depended strongly on specific features of the cultures involved; however, its results are widely and trans-culturally accepted and applied.
Gierer, Alfred
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
PRICE DISCOVERY MECHANISMS AND ALTERNATIVES FOR CANADIAN AGRICULTURE; Part I: A Review of Pricing Mechanisms in Agriculture [PDF]
The purpose of this section is to review pricing mechanisms in agriculture and food. We started by constructing a taxonomy and system of classification for pricing mechanisms that is rooted in economic theory.
Grier, Kevin +4 more
core +1 more source