Results 221 to 230 of about 2,477,378 (287)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Transcriptome and Metabolome-Based Analysis Reveals the Molecular Mechanisms Underlying the Differences in Tanshinone and Salvianolic Acid Content Between <i>Salvia miltiorrhiza</i> Roots and Leaves. [PDF]

Genes (Basel)
Liu F, Xu Y, Pan L, Zhang Y, Ding M.
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Dissecting the ROS signalling component of salinity tolerance: tissue-specific K+/Na+ homeostasis in quinoa and spinach roots. [PDF]

J Exp Bot
Tanveer M, Bilal MS, Chen ZH, Wang L, Shabala S.   +4 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Integrated Biochemical and Ultrastructural Responses of <i>Tanacetum vulgare</i> L. to Multi-Metal Stress. [PDF]

Plants (Basel)
Alliluev I, Chernikova N, Kazachkova V, Ahmad I, Fedorenko A, Popov V, Babenko A, Chaplygin V, Mandzhieva S, Minkina T.   +9 more
europepmc   +1 more source

Phytochemical Composition and Bioactivity of <i>Acanthus dioscoridis</i> var. <i>perringii</i>: An Integrated Analysis of Antioxidant Activity, Enzyme Inhibition, and Phenolic-Bioactivity Correlations. [PDF]

Pharmaceuticals (Basel)
Selvi B.
europepmc   +1 more source

Exogenous melatonin alleviates copper stress in apple rootstock M9T337 by regulating the antioxidant system and carbon-nitrogen metabolism. [PDF]

Front Plant Sci
Wang F, Zhang J, Hao X, Peng L, Ding S, Zhao C, Liu L, Ji X, Zhao X, Sun M, Xu R.   +10 more
europepmc   +1 more source

Cullin 3 substrate-adaptor protein 1 (MtCSP1) modulates nodulation through interaction with the GTPase ARFA1. [PDF]

Sci Rep
Rípodas C, Cretton M, Eylenstein A, Rivero C, Zanetti ME, Blanco F.   +5 more
europepmc   +1 more source

In vitro adventitious root culture of Withania somnifera L.: a strategy for enhanced secondary metabolite production with therapeutic antioxidant and anti-inflammatory potential. [PDF]

Sci Rep
Mohammed DM, Abdelazeez WMA, Suliman AA, Sallam ARM, Sief-Eldein AGM, Aboueldis GR.   +5 more
europepmc   +1 more source