Results 51 to 60 of about 41,805 (255)

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

“Oxygen with Love” and Diode Laser Treatment Decreases Comorbidity and Avoidable Blindness due to Retinopathy of Prematurity: Results Achieved in the Past 12 Years

Pediatrics and Neonatology, 2013
To determine whether the “Oxygen with Love” (OWL) and diode laser treatment provided in a neonatal intensive care unit has reduced the risk of avoidable blindness caused by retinopathy of prematurity (ROP) over the past decade.
Jose Luis Garcia-Serrano, José Uberos Fernández, Roberto Anaya-Alaminos, Antonio Jerez-Calero, José Francisco Padilla-Torres, Maria Carmen Ramírez-Garcia, Raquel Piñar-Molina   +6 more
doaj   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Improved screening of retinopathy of prematurity (ROP): development of a target product profile (TPP) for resource-limited settings

BMJ Open Ophthalmology, 2023
Background As more preterm infants survive, complications of preterm birth, including retinopathy of prematurity (ROP), become more prevalent. ROP rates and blindness from ROP are higher in low-income and middle-income countries, where exposure to risk factors can be higher and where detection and treatment of ROP ...
Clare E Gilbert, Andrea Zin, Cindy McWhorter, Pukhraj Rishi, Chinyere Ezeaka, Aeesha N J Malik, Dupe S Ademola-Popoola, Odirichi Andrew, Julio A Urrets-Zavalia, Anand Vinekar, Rebecca P Kirby, Kara M Palamountain, Afsar Dastjani Farahani, Alex Pennos, Antonio Castilla Bombín, Ashish N Holani, Elizabeth Asma, Dharma Irugalbandara, Sarah Sitati, Sriharanathan Poopalaratnam, Emeka Ikediugwu, Francis Mutangana, Gilbert Batieka Bonsaana, Guillermo Andres Monteoliva, J Peter Campbell, K Chandrasekhar, Lindsay Hampton-Hampejskova, Nigel Bolster, Nilva Simeren BuenoDeMores, Oluwatimilehin Abayomi, Rilwan Chiroma Muhammad, Roberto Yee, R V Paul Chan   +32 more
openaire   +3 more sources

High-speed PAM4-based Optical SDM Interconnects with Directly Modulated Long-wavelength VCSEL

, 2018
This paper reports the demonstration of high-speed PAM-4 transmission using a 1.5-{\mu}m single-mode vertical cavity surface emitting laser (SM-VCSEL) over multicore fiber with 7 cores over different distances.
Amann, Markus-Christian, Bauwelinck, Johan, Chen, Jiajia, Fu, Songnian, Gan, Lin, Jacobsen, Gunnar, Li, Haolin, Lin, Rui, Liu, Deming, Ozolins, Oskars, Pang, Xiaodan, Popov, Sergei, Schatz, Richard, Spiga, Silvia, Tang, Ming, Tong, Weijun, Torfs, Guy, Udalcovs, Aleksejs, Van Kerrebrouck, Joris, Yin, Xin, Zhang, Lu   +20 more
core   +1 more source

Simultaneously improving ROP and maintaining wellbore stability in shale gas well: A case study of Luzhou shale gas reservoirs

Rock Mechanics Bulletin
The ROP (rate of penetration) within the horizontal section of shale gas wells in the Luzhou oil field is low, seriously delaying the exploration and development process.
Yaoran Wei, Yongcun Feng, Zhenlai Tan, Tianyu Yang, Shuang Yan, Xiaorong Li, Jingen Deng   +6 more
doaj   +1 more source

A Note on Predicting Rate of Penetration Using Machine Learning Models [PDF]

JES: Journal of Engineering Sciences
Rate of Penetration (ROP) is a critical parameter influencing drilling efficiency and accelerating field development. Although conventional ROP models (e.g., Bourgoyne, Hareland) provided reasonable results, they often struggle with limited accuracy and ...
Ahmad Husseiny, Attia Attia, Ahmed Hagag
doaj   +1 more source

To Study the Incidence and Risk Factors of Retinopathy of Prematurity in Himachal Pradesh

Delhi Journal of Ophthalmology
Background: Retinopathy of prematurity (ROP) is a disease of developing immature blood vessels in the retina of premature neonates. With the recent advances in neonatal care, there has been improvement in rates of survival in premature infants.
Richa Sharma, Rajeev Tuli, Gaurav Sharma, Indu Dhiman, Piyush Gautam   +4 more
doaj   +1 more source

Results of surgery for late sequelae of cicatricial retinopathy of prematurity

Indian Journal of Ophthalmology, 2019
Purpose: To report anatomical and functional results of vitreoretinal surgery in our case series of late cicatricial retinopathy of prematurity (ROP) patients with subtotal retinal detachment.
Hatice Tuba Atalay, Şengül Özdek, Duygu Yalınbaş, Cemal Özsaygılı, Mehmet Cüneyt Özmen   +4 more
doaj   +1 more source

Enhanced Rheological and Filtration Performance of Drilling Fluids Using Fe3O4/Saponin/Cu(II) Nanocomposites: Synthesis, Characterization, and Application

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Drilling fluids used in high‐performance well operations often struggle to maintain rheological stability, colloidal dispersion, and filtration control under harsh downhole conditions. This study engineered a multifunctional Fe3O4@Saponin/Cu(II) nanocomposite to address these challenges.
Kassem Al Attabi, Farag M. A. Altalbawy, Hana Ihsan Hassan, Ahmed Salih Sahib, Zahraa Saad Abdulali, Mariem Alwan, Mahmood Jawad, Hiba Mushtaq, Aseel Smerat, Fatimah Pashtun   +9 more
wiley   +1 more source