Results 71 to 80 of about 9,069,962 (304)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

CNNs on surfaces using rotation-equivariant features

ACM Transactions on Graphics, 2020
This paper is concerned with a fundamental problem in geometric deep learning that arises in the construction of convolutional neural networks on surfaces. Due to curvature, the transport of filter kernels on surfaces results in a rotational ambiguity, which prevents a uniform alignment of these kernels on the surface. We propose a network architecture
Ruben Wiersma, Elmar Eisemann, Klaus Hildebrandt   +2 more
openaire   +5 more sources

Rotational energy surfaces of molecules exhibiting internal rotation [PDF]

The Journal of Chemical Physics, 1994
Rotational energy surfaces [W. G. Harter and C. W. Patterson, J. Chem. Phys. 80, 4241 (1984)] for a molecule with internal rotation are constructed. The study is limited to torsional states at or below the top of the barrier to internal rotation, where the extra (torsional) degree of freedom can be eliminated by expanding eigenvalues of the torsion–K ...
Ortigoso, Juan, Hougen, Jon T.
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Rotation Systems and Simple Drawings in Surfaces

The Electronic Journal of Combinatorics
Every simple drawing of a graph in the plane naturally induces a rotation system, but it is easy to exhibit a rotation system that does not arise from a simple drawing in the plane. We extend this to all surfaces: for every fixed surface $\Sigma$, there is a rotation system that does not arise from a simple drawing in $\Sigma$.
Rosna Paul, Gelasio Salazar, Alexandra Weinberger   +2 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Comparative study of rotational and longitudinal turning: Energy efficiency and surface roughness in machining normalized medium-carbon steel [PDF]

FME Transactions
This study compares rotational and longitudinal turning during the machining of normalized medium-carbon steel. The aim is to evaluate differences in energy efficiency and surface quality.
Sztankovics István, Rodić Dragan
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Liquid Atomization Using a Rotary Bell Cup Atomizer

Journal of Fluid Science and Technology, 2010
This present study investigates liquid flow patterns on the inner surface of a rotary bell cup atomizer and the effect of these flow patterns on the breakup patterns at the edge of the rotary bell cup.
Shin OGASAWARA, Masatoshi DAIKOKU, Minori SHIROTA, Takao INAMURA, Yasuhiro SAITO, Kotaro YASUMURA, Masakazu SHOJI, Hideyuki AOKI, Takatoshi MIURA   +8 more
doaj   +1 more source