Results 141 to 150 of about 429,183 (289)

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source

A 52‐Week Efficacy and Safety Study of Teneligliptin, as an Add‐On to Empagliflozin and Metformin in Patients With Type 2 Diabetes Mellitus: A Randomised, Double‐Blind, Placebo‐Controlled Phase 3 Trial (TERA305 Study)

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the long‐term efficacy and safety of teneligliptin add‐on in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin and empagliflozin. Materials and Methods In this randomised, double‐blind, phase 3 trial, 214 patients received teneligliptin 20 mg (n = 107) or placebo (n = 107) once daily for 24 ...
Jun Sung Moon, Kyung Ah Han, Dong‐Lim Kim, Sang Yong Kim, Soo‐Kyung Kim, Bon Jeong Ku, Woo Je Lee, Tae Keun Oh, Ji A Seo, Sang‐Ah Chang, Moon‐Kyu Lee, Kyu Jeung Ahn, Chul Sik Kim, Tae Nyun Kim, Bong‐Soo Cha   +14 more
wiley   +1 more source

Utility of the SWAM (Separator With Aspirator for Mechanical Thrombectomy) Device in Managing Hemodialysis Access Thrombosis

Hemodialysis International, EarlyView.
ABSTRACT Background Hemodialysis access thrombosis is the primary cause of access failure. Thrombus removal is an effective strategy to restore access function. Although both open surgical and endovascular procedures enable thrombus clearance, endovascular thrombus reduction therapy is widely adopted in clinical practice for this condition due to its ...
Lin Li, Zhongwang Zhang, Hongjie Wang, Mingdi Zhu, Kun Wang, Zheng Liu   +5 more
wiley   +1 more source

Veterinary point‐of‐care ultrasound probe orientation and location for detection of pleural effusion in canine cadavers: a pilot study

Journal of Small Animal Practice, EarlyView.
Objectives To evaluate whether point‐of‐care ultrasound probe location (at or below the costochondral junction) and probe orientation (perpendicular or parallel to the ribs) affect operator ability to detect pleural effusion in a canine cadaver model.
C. Di Franco, J. Menard, A. Romero, S. Chalhoub, V. Madden, S. R. Boysen   +5 more
wiley   +1 more source

Policing the safety net: Medical and carceral management of violence in a Los Angeles County public hospital

Medical Anthropology Quarterly, EarlyView.
Abstract Medical anthropologists have long shown how hospitals function as spaces of both care and control, yet the entanglement of policing and trauma care remains understudied. This paper offers an ethnographic account of how trauma surgeons in a Los Angeles County hospital navigate the embedded presence of police within their clinical work.
Emily Virginia Jones
wiley   +1 more source

Arthroscopic Upper Third Subscapularis Tendon Repair Using H‐Loop Technique: A Case Series

Orthopaedic Surgery, Volume 17, Issue 5, Page 1525-1535, May 2025.
The images show the surgical technique. (a) Partial subscapularis tendon tear; (b) A PDS suture is passed through the medial and distal edges of the tear and tied at the end to bring in a #2 Fiber Wire suture; (c) Another PDS suture is passed through the tear and inside the loop; (d) The end of the PDS suture is tied, securing both tails of the #2 ...
Yi‐Tao Yang, Zhuo Wang, Chen‐Yang Meng, Xing‐Hao Deng, Yi Long, Jing‐Yi Hou, Rui Yang   +6 more
wiley   +1 more source

Clinical Outcomes of an Improved Arthroscopic Suture‐Bridge Technique Assisted by a “5 O'clock” Portal for Acute Bony Bankart Lesions

Orthopaedic Surgery, EarlyView.
This modified arthroscopic suture‐bridge technique, utilizing a unique “5 o'clock” portal, achieves reliable perpendicular fixation for bony Bankart lesions, reducing mean glenoid bone loss from 18.2% to 2.5% (p < 0.001) with a 97.2% healing rate and 80% return‐to‐sport rate. ABSTRACT Purpose Bony Bankart lesion is a primary cause of traumatic shoulder
Fan Jiang, Qing Yang, Chao Qi, Yi Zhang, Jinlong Ma, Tengbo Yu, Youliang Shen   +6 more
wiley   +1 more source

A comparison of the neuromuscular, cardiopulmonary and muscle oxygenation responses to single‐ and double‐leg cycling in older adults

Experimental Physiology, EarlyView.
Abstract Previous work in younger adults has shown that during small muscle mass exercise, the tolerable degree of neuromuscular impairment at task failure is greater than during large muscle mass exercise. However, no study has compared the neuromuscular responses to small and large muscle mass exercise whilst matching exercise modality in older ...
Emily Dodd, Callum G. Brownstein
wiley   +1 more source

Peripheral regeneration of Aβ low‐threshold mechanoreceptors is limited despite activation of regenerative transcriptional pathways

The Journal of Physiology, EarlyView.
Abstract figure legend The regeneration of Aβ low‐threshold mechanoreceptors (Aβ‐LTMRs), sensory neurons responsible for discriminative touch, has not previously been explored. Here, we took advantage of the selective expression of Calb1 in Aβ‐LTMRs to generate two genetic mouse models for studying their regenerative response after nerve injury.
Sara Bolívar, Natàlia Martínez‐Mateu, David Ovelleiro, Esther Udina   +3 more
wiley   +1 more source

Aquaporin‐4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age‐Related Muscle Decline

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 6, December 2026.
ABSTRACT Background Impaired muscle regeneration is a key contributor to age‐related muscle decline, yet the molecular mechanisms linking muscle water homeostasis to regenerative failure remain incompletely understood. Aquaporin‐4 (AQP4), a major skeletal muscle water channel, may have functions beyond water transport that are relevant to muscle ...
María D. Girón, Manuel Manzano, Suzette L. Pereira, Antonio Reinoso, Chiara Burgio, Nora Montero‐Martin, Guillermo Jiménez‐Jiménez, Josep M. Argilés, Ricardo Rueda, José M. López‐Pedrosa, Rafael Salto   +10 more
wiley   +1 more source