Results 21 to 30 of about 48,392 (124)

Statins significantly repress rotavirus replication through downregulation of cholesterol synthesis

Gut Microbes, 2021
Rotavirus is the most common cause of severe diarrhea among infants and young children and is responsible for more than 200,000 pediatric deaths per year.
Shihao Ding, Bingting Yu, Anneke J. van Vuuren   +2 more
doaj   +1 more source

Rotavirus gastroenteritis in children hospitalized in northeastern Poland in 2006–2020: Severity, seasonal trends, and impact of immunization

International Journal of Infectious Diseases, 2021
Objectives: The introduction of the rotavirus vaccine in 2006 significantly reduced childhood incidence of acute gastroenteritis (AGE) worldwide. The rotavirus vaccine was included in Poland’s national immunization program in 2021.
Kacper Toczylowski, Katarzyna Jackowska, Dawid Lewandowski, Sandra Kurylonek, Marlena Waszkiewicz-Stojda, Artur Sulik   +5 more
doaj   +1 more source

Reinfecções por rotavírus em crianças de Belém, Pará, Brasil

Revista do Instituto de Medicina Tropical de São Paulo, 1986
Reinfecções por rotavírus foram detectadas em 7 (9,2%) de 76 crianças habitantes da periferia de Belém, Pará, Brasil, no decurso de seus primeiros 20 meses de vida.
Alexandre C. Linhares, Ronaldo B. Freitas, Yvone B. Gabbay, Joana D'arc M. Pereira   +3 more
doaj   +1 more source

Results and prospects of rotavirus immunisation in the Russian Federation

Биопрепараты: Профилактика, диагностика, лечение, 2023
Scientific relevance. Rotavirus disease and its consequences remain a leading vaccine-preventable cause of mortality in young children. Russia has not yet included rotavirus immunisation in the national vaccination schedule, but paediatric rotavirus ...
A. S. Korovkin, G. M. Ignatyev
doaj   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Impact of rotavirus vaccine introduction in Abidjan, Côte d’Ivoire

Human Vaccines & Immunotherapeutics, 2023
Côte d’Ivoire introduced rotavirus vaccine in March 2017. Rotavirus surveillance is conducted at Centre Hospitalier Universitaire de Yopougon in Abidjan, the capital city. Children
Alice Britoh Mlan, Rachel M. Burke, Hamidou Koné, Catherine Boni-Cisse, Rebecca N’Guessan, Flore Zaba, Lepri Nicaise Aka, Kofi N’Zue, San Koffi Adom, Sié Kabran Kouadio, Armel Bhérat Kouadio, Syndou Meité, Stephane Koffi, Hortense Faye-Kette, Keith Shaba, Bernard Ntsama, Joseph Biey, Negar Aliabadi, Jason M. Mwenda, Umesh D. Parashar, Jacqueline E. Tate   +20 more
doaj   +1 more source

A Novel Rotavirus Reverse Genetics Platform Supports Flexible Insertion of Exogenous Genes and Enables Rapid Development of a High-Throughput Neutralization Assay

Viruses, 2023
Despite the success of rotavirus vaccines, rotaviruses remain one of the leading causes of diarrheal diseases, resulting in significant childhood morbidity and mortality, especially in low- and middle-income countries. The reverse genetics system enables
Jiajie Wei, Scott Radcliffe, Amanda Pirrone, Meiqing Lu, Yuan Li, Jason Cassaday, William Newhard, Gwendolyn J. Heidecker, William A. Rose II, Xi He, Daniel Freed, Michael Citron, Amy Espeseth, Dai Wang   +13 more
doaj   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Dietary Mannan‐Rich Fractions Attenuate Weaning Stress in Piglets via Modulating Gut Microbiota and TLR5/NF‐κB Signaling

Animal Research and One Health, EarlyView.
This study aimed to investigate the potential of a mannan‐rich fraction (MRF) as a dietary intervention to alleviate weaning stress in piglets. Our results revealed that MRF could alleviate weaning stress by modulating the gut microbiota and the TLR5/NF‐κB signaling pathway, offering a novel and sustainable alternative to antibiotic use in swine ...
Yutong Lu, Yiwei Sun, Kun Cai, Pingli He, Gang Lin, Zengkai Qi, Hu Liu, Junshu Yan, Ning Ma   +8 more
wiley   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source