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Rotavirus [PDF]

open access: yesEmerging Infectious Diseases, 1998
Rotavirus, the most common diarrheal pathogen in children worldwide, causes approximately one third of diarrhea-associated hospitalizations and 800,000 deaths per year. Because natural infection reduces the incidence and severity of subsequent episodes, rotavirus diarrhea might be controlled through vaccination.
Umesh D. Parashar   +3 more
openaire   +3 more sources

Putative E3 Ubiquitin Ligase of Human Rotavirus Inhibits NF-κB Activation by Using Molecular Mimicry To Target β-TrCP

open access: yesmBio, 2015
NF-κB plays a critical role in the induction and maintenance of innate and adaptive immune transcriptional programs. An associated inhibitor of κB protein (IκB) regulates NF-κB activation and contains a degron motif (DSGΦxS) that undergoes ...
Marco Morelli   +2 more
doaj   +1 more source

Rotavirus gastroenteritis in children hospitalized in northeastern Poland in 2006–2020: Severity, seasonal trends, and impact of immunization

open access: yesInternational Journal of Infectious Diseases, 2021
Objectives: The introduction of the rotavirus vaccine in 2006 significantly reduced childhood incidence of acute gastroenteritis (AGE) worldwide. The rotavirus vaccine was included in Poland’s national immunization program in 2021.
Kacper Toczylowski   +5 more
doaj   +1 more source

Rotavirus specific maternal antibodies and immune response to RV3-BB neonatal rotavirus vaccine in New Zealand

open access: yesHuman Vaccines & Immunotherapeutics, 2017
Background: Maternal antibodies, acquired passively via placenta and/or breast milk, may contribute to the reduced efficacy of oral rotavirus vaccines observed in children in developing countries.
Mee-Yew Chen   +9 more
doaj   +1 more source

Genotypic characterization of rotavirus in children under 5 years circulating in Côte D’Ivoire from 2010 to 2013

open access: yesVirology Journal, 2018
Background Rotavirus infection is the most common cause of severe gastroenteritis in children under five years of age in both developed and developing countries.
Catherine Boni-cisse   +6 more
doaj   +1 more source

Results and prospects of rotavirus immunisation in the Russian Federation

open access: yesБиопрепараты: Профилактика, диагностика, лечение, 2023
Scientific relevance. Rotavirus disease and its consequences remain a leading vaccine-preventable cause of mortality in young children. Russia has not yet included rotavirus immunisation in the national vaccination schedule, but paediatric rotavirus ...
A. S. Korovkin, G. M. Ignatyev
doaj   +1 more source

Impact of rotavirus vaccine introduction in Abidjan, Côte d’Ivoire

open access: yesHuman Vaccines & Immunotherapeutics, 2023
Côte d’Ivoire introduced rotavirus vaccine in March 2017. Rotavirus surveillance is conducted at Centre Hospitalier Universitaire de Yopougon in Abidjan, the capital city. Children
Alice Britoh Mlan   +20 more
doaj   +1 more source

Rotavirus

open access: yesMicrobiology Spectrum, 2013
ABSTRACTRotaviruses (RV) are ubiquitous, highly infectious, segmented double-stranded RNA genome viruses of importance in public health because of the severe acute gastroenteritis they cause in young children and many animal species. They are very well adapted to their host, with symptomatic and asymptomatic reinfections being virtually universal ...
Franco, Manuel A., Greenberg, Harry B.
openaire   +3 more sources

A Novel Rotavirus Reverse Genetics Platform Supports Flexible Insertion of Exogenous Genes and Enables Rapid Development of a High-Throughput Neutralization Assay

open access: yesViruses, 2023
Despite the success of rotavirus vaccines, rotaviruses remain one of the leading causes of diarrheal diseases, resulting in significant childhood morbidity and mortality, especially in low- and middle-income countries. The reverse genetics system enables
Jiajie Wei   +13 more
doaj   +1 more source

Maintaining Momentum for Rotavirus Immunization in Africa during the COVID-19 Era: Report of the 13th African Rotavirus Symposium

open access: yesVaccines, 2022
The 13th African Rotavirus Symposium was held as a virtual event hosted by the University of Nairobi, Kenya and The Kenya Paediatric Association on 3rd and 4th November 2021.
Frederick N. Were   +5 more
doaj   +1 more source

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