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Rotavirus, the most common diarrheal pathogen in children worldwide, causes approximately one third of diarrhea-associated hospitalizations and 800,000 deaths per year. Because natural infection reduces the incidence and severity of subsequent episodes, rotavirus diarrhea might be controlled through vaccination.
Umesh D. Parashar +3 more
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NF-κB plays a critical role in the induction and maintenance of innate and adaptive immune transcriptional programs. An associated inhibitor of κB protein (IκB) regulates NF-κB activation and contains a degron motif (DSGΦxS) that undergoes ...
Marco Morelli +2 more
doaj +1 more source
Objectives: The introduction of the rotavirus vaccine in 2006 significantly reduced childhood incidence of acute gastroenteritis (AGE) worldwide. The rotavirus vaccine was included in Poland’s national immunization program in 2021.
Kacper Toczylowski +5 more
doaj +1 more source
Background: Maternal antibodies, acquired passively via placenta and/or breast milk, may contribute to the reduced efficacy of oral rotavirus vaccines observed in children in developing countries.
Mee-Yew Chen +9 more
doaj +1 more source
Background Rotavirus infection is the most common cause of severe gastroenteritis in children under five years of age in both developed and developing countries.
Catherine Boni-cisse +6 more
doaj +1 more source
Results and prospects of rotavirus immunisation in the Russian Federation
Scientific relevance. Rotavirus disease and its consequences remain a leading vaccine-preventable cause of mortality in young children. Russia has not yet included rotavirus immunisation in the national vaccination schedule, but paediatric rotavirus ...
A. S. Korovkin, G. M. Ignatyev
doaj +1 more source
Impact of rotavirus vaccine introduction in Abidjan, Côte d’Ivoire
Côte d’Ivoire introduced rotavirus vaccine in March 2017. Rotavirus surveillance is conducted at Centre Hospitalier Universitaire de Yopougon in Abidjan, the capital city. Children
Alice Britoh Mlan +20 more
doaj +1 more source
ABSTRACTRotaviruses (RV) are ubiquitous, highly infectious, segmented double-stranded RNA genome viruses of importance in public health because of the severe acute gastroenteritis they cause in young children and many animal species. They are very well adapted to their host, with symptomatic and asymptomatic reinfections being virtually universal ...
Franco, Manuel A., Greenberg, Harry B.
openaire +3 more sources
Despite the success of rotavirus vaccines, rotaviruses remain one of the leading causes of diarrheal diseases, resulting in significant childhood morbidity and mortality, especially in low- and middle-income countries. The reverse genetics system enables
Jiajie Wei +13 more
doaj +1 more source
The 13th African Rotavirus Symposium was held as a virtual event hosted by the University of Nairobi, Kenya and The Kenya Paediatric Association on 3rd and 4th November 2021.
Frederick N. Were +5 more
doaj +1 more source

