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Pediatric Infectious Disease Journal, 2006
The twin objectives of all vaccines are safety and efficacy. In the case of rotavirus vaccine for humans safety and efficacy initially was sought through oral administration of related viruses indigenous to animals but the assumption that these viruses are harmless to humans appeared to be only partly correct.
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The twin objectives of all vaccines are safety and efficacy. In the case of rotavirus vaccine for humans safety and efficacy initially was sought through oral administration of related viruses indigenous to animals but the assumption that these viruses are harmless to humans appeared to be only partly correct.
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Rotavirus Vaccines and Vaccination Potential
1994The development of a successful rotavirus vaccine is a complex problem. Our review of rotavirus vaccine development shows that many challenges remain, and priorities for future studies need to be established. For example, the evaluation of administration of a vaccine with OPV or breast milk might receive less emphasis until a vaccine is made that shows
M E, Conner, D O, Matson, M K, Estes
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Designing spatial and temporal control of vaccine responses
Nature Reviews Materials, 2021Shih Hao Ou, Wei Luo, Bali Pulendran
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Rotavirus vaccines [Rotavirus aşilari]
2019Rotavirus is a major cause of acute gastroenteritis worldwide and infects almost all children in the first 5 years of life, with severe, dehydrating gastroenteritis occurring primarily among children 4 to 36 months of age. Rotavirus causes an estimated 600.000 deaths and more than 2 million hospitalizations each year.
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COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials
Nature Reviews Clinical Oncology, 2021Aakash Desai +2 more
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Emerging concepts in the science of vaccine adjuvants
Nature Reviews Drug Discovery, 2021Bali Pulendran, Prabhu S Arunachalam
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