Results 51 to 60 of about 909,546 (299)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Federated Multi-Label Feature Selection via Anchor-Guided Frequency-Domain Optimization Algorithm

Algorithms
Multi-label text feature selection aims to identify compact and discriminative feature subsets for documents associated with multiple correlated labels.
Yuxue Hu, Yawen Yan, Li Zhao, Zhiwei Ye, Zhuo Luo, Songsong Zhang, Ting Cai   +6 more
doaj   +1 more source

Bland-Altman plots for Rad-97 respiratory rate (RR) median.

, 2022
(A) Open-label round. (B) Closed-label round one. (C) Closed-label round two. (D) Closed-label round three. Colors indicate which enrolled neonate is associated with the measurement pair.
J. Mark Ansermino (8929673), William Macharia (12981923), Roseline Ochieng (12981926), Dorothy Chomba (12981929), Dustin Dunsmuir (576516), Shuai Xu (147659), Amy Sarah Ginsburg (10191988), Jesse Coleman (12981920), Guohai Zhou (576517)   +8 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Bland-Altman plots for heart rate (HR).

, 2022
(A) Open-label round. (B) Closed-label round one. (C) Closed-label round two. (D) Closed-label round three. Colors indicate which enrolled neonate is associated with the measurement pair.
J. Mark Ansermino (8929673), William Macharia (12981923), Roseline Ochieng (12981926), Dorothy Chomba (12981929), Dustin Dunsmuir (576516), Shuai Xu (147659), Amy Sarah Ginsburg (10191988), Jesse Coleman (12981920), Guohai Zhou (576517)   +8 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Learning to Round for Discrete Labeling Problems.

, 2018
Discrete labeling problems are often solved by formulating them as an integer program, and relaxing the integrality constraint to a continuous domain. While the continuous relaxation is closely related to the original integer program, its optimal solution is often fractional. Thus, the success of a relaxation depends crucially on the availability of an
Mohapatra, P, Jawahar, C, Mudigonda, P
openaire   +2 more sources