Results 151 to 160 of about 6,528 (262)

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Real‐Time Ferroelectric Domain Wall Dynamics During Electric Poling and Depoling

Advanced Science, EarlyView.
Real‐time visualization of domain wall dynamics during alternating‐current poling, direct‐current poling, and electrical depoling in relaxor‐PT ferroelectric single crystals reveals distinct field‐dependent pathways and strong path dependence. Instant polarized light microscopy uncovers reversible domain wall nucleation, motion, and reconfiguration ...
Ziqi Wang, Zhengze Xu, Anastasia Timofeeva, Hossam Elnaggar, Sipan Liu, Yusen Pei, Reece Henry, Brendan O'Connor, Eunkyoung Shim, Franky So, Kara Peters, Xiaoning Jiang, Jun Liu   +12 more
wiley   +1 more source

<i>ROBO2</i> Variants Associated With Atrial Septal Defect Define a Novel Regulatory Element. [PDF]

Circ Genom Precis Med
Kim SW, Parfenov M, Rodriguez-Murillo L, Conner DA, Sharma A, Peter I, Xiao F, Layton O, Tai A, Ward T, Wasson LK, Gorham JM, Mazaika E, Lagomarsino VN, Young-Pearse TL, Goldmuntz E, Wakimoto H, Agopian AJ, McKean DM, DePalma SR, Pu WT, Seidman CE, Gelb BD, Seidman JG, PCGC Investigators.   +24 more
europepmc   +1 more source

Stretchable, Tough, and Luminescent Perovskite Molecular Ferroelectric Composite: Empowering Reliable Self‐Powered Motion Sensing in High Humidity and Subzero Temperatures

Advanced Science, EarlyView.
A flexible molecular ferroelectric composite is fabricated via in situ growth of luminescent DMAA‐MnCl3 ferroelectric crystals within a SEBS/SIS double‐polymer matrix. It delivers 7.54 MPa tensile strength, over 1200% tensile strain, durable piezoelectric motion sensing, and excellent harsh‐environment stability for all‐weather wearable biomechanical ...
Shuangqing Li, Zhe‐Kun Xu, Zheng Xing, Jin‐Wang Liu, Yong‐Quan Wu, Peng‐Fei Li, Zhong‐Xia Wang   +6 more
wiley   +1 more source

Advances in Wood and Wood Polymer Composites. [PDF]

Polymers (Basel)
Papadopoulos AN.
europepmc   +1 more source

Facet‐Dependent Activity of Fe3S4 Crystal in Peroxydisulfate Activation for Organic Pollutants Degradation

Advanced Science, EarlyView.
Fe3S4 crystal with the exposed [001] facet exhibits higher catalytic activity for activating peroxydisulfate (PDS) to degrade clothianidin (CLO), which can be attributed to the dissolved Fe‐induced homogeneous catalytic process; while Fe3S4 crystal with the exposed [1‐21] facet exhibits excellent catalytic stability and durability, thereby boosting the
Jiaqu Tan, Min Yu, Jinfeng Wang, Dongya Li, Fan Yang, Yulong Zhang, Xueming Lin   +6 more
wiley   +1 more source

Evaluating the effectiveness of speed humps and rumble strips in improving pedestrian safety in Addis Ababa, Ethiopia. [PDF]

PLoS One
Tulu GS, Lisinge RT, Tarekegn AG, Eshetu T.   +3 more
europepmc   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Assessing the Safety and Efficacy of Agonistic Monoclonal Antibody against Robo4 versus Ranibizumab in Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema: A Phase I, Open-Label, Multicenter Study. [PDF]

Ophthalmol Sci
Afridi R, Senaldi G, Hwang JJ, Nguyen N, Inoue T, Berger B, Patel S, Fazal ZZ, Nguyen QD, Sepah Y.   +9 more
europepmc   +1 more source

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source