Results 201 to 210 of about 175,165 (277)

National Survey on Very Low Birth Weight Starter Parenteral Nutrition. [PDF]

J Pediatr Pharmacol Ther
Jun JE, Siver M, Robinson CA, Siu A, Meyers RS, Shah P.   +5 more
europepmc   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Development of a high-throughput screening platform for <i>C. difficile</i> toxin synthesis inhibitors unveils meclizine as an antivirulence agent. [PDF]

Antimicrob Agents Chemother
Marreddy RKR, Nguyen N, Dureja C, McKelvey AM, Powell R, Olaitan AO, Stephan C, Hurdle JG.   +7 more
europepmc   +1 more source

A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions

Advanced Science, EarlyView.
This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies, Emanuele Nicotra, Kefan Zhu, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Phuoc Thien Phan, Jingjing Wan, Patrick Pruscino, Hermione Truong, Jelena Rnjak‐Kovacina, Hoang‐Phuong Phan, Christopher Hayward, Nigel Hamilton Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

Using SCORE2 with a risk chart or online calculator: impact on model performance, treatment eligibility, and cardiovascular disease prevention. [PDF]

Eur Heart J Qual Care Clin Outcomes
Hageman SHJ, Kaptoge S, Gynnild MN, Holtrop J, Pennells L, McEvoy JW, Bobak M, Pająk A, Pikhart H, Tamosiunas A, Smulders YM, Mach F, Carballo D, Steyerberg EW, Dorresteijn JAN, Di Angelantonio E, Wood AM, Visseren FLJ.   +17 more
europepmc   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Error Resilient Space Partitioning. [PDF]

Discrete Comput Geom
Dunkelman O, Geyzel Z, Keller C, Keller N, Ronen E, Shamir A, Tessler RJ.   +6 more
europepmc   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Adaptive Ketogenic-Mediterranean Protocol (AKMP) in Real Clinical Practice: 14-Week Pre-Post Cohort Study on Glucolipid Markers and Safety. [PDF]

Nutrients
García-Gorrita C, San Onofre N, Merino-Torres JF, Soriano JM.   +3 more
europepmc   +1 more source

Round off error analysis based on Weighted Pushdown Model checking

Round off error analysis based on Weighted Pushdown Model checking
JAIST 21世紀COEシンポジウム2008「検証進化可能電子社会」= JAIST 21st Century COE Symposium 2008 Verifiable and Evolvable e-Society, 開催：2008年3月3日～4日, 開催場所：北陸先端科学技術大学院大学 GRP研究員発表会　セッションB-3発表資料 identifier:https://dspace.jaist.ac.jp/dspace/handle/10119 ...
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