Results 51 to 60 of about 234,648 (292)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Symmetric and Asymmetric Rounding [PDF]
, 2006 If rounded data are used in estimating moments and regression coefficients, the estimates are typically more or less biased. The purpose of the paper is to study the bias inducing effect of rounding, which is also seen when population moments instead of ...
Ahmad, A. +2 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Normalizing or not normalizing? An open question for floating-point arithmetic in embedded systems [PDF]
, 2017 Emerging embedded applications lack of a specific standard when they require floating-point arithmetic. In this situation they use the IEEE-754 standard or ad hoc variations of it. However, this standard was not designed for this purpose. This paper aims
Gonzalez-Navarro, Sonia +1 more
core +2 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Metabolic traits specific for lipid-overproducing strain of Mucor circinelloides WJ11 identified by genome-scale modeling approach [PDF]
PeerJ, 2019 The genome-scale metabolic model of a lipid-overproducing strain of Mucor circinelloides WJ11 was developed. The model (iNI1159) contained 1,159 genes, 648 EC numbers, 1,537 metabolites, and 1,355 metabolic reactions, which were localized in different ...
Nattapat Isarankura Na Ayudhya +4 more
doaj +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
An efficient rounding boundary test for pow(x,y) in double precision [PDF]
, 2007 18 pagesThe correct rounding of the function pow: (x,y) -> x^y is currently based on Ziv's iterative approximation process. In order to ensure its termination, cases when x^y falls on a rounding boundary must be filtered out. Such rounding boundaries are
Lauter, Christoph, Lefèvre, Vincent
core +1 more source
Improving Fixed-Point Implementation of QR Decomposition by Rounding-to-Nearest [PDF]
, 2015 QR decomposition is a key operation in many current communication systems. This paper shows how to reduce the area of a fixed-point QR decomposition implementation based on Givens rotations by using a new number representation system.
Hormigo-Aguilar, Javier +1 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source