Results 91 to 100 of about 1,154,427 (304)

Intrahepatic injection of recombinant adeno-associated virus serotype 2 overcomes gender-related differences in liver transduction [PDF]

, 2006
The liver is an attractive organ for gene therapy because of its important role in many inherited and acquired diseases. Recombinant adeno-associated viruses (rAAVs) have been shown to be good candidates for liver gene delivery, leading to long-term gene
Berraondo, P. (Pedro), Crettaz, J. (Julien), González-Aseguinolaza, G. (Gloria), Ochoa, L. (Laura), Pañeda, A. (Astrid), Prieto, J. (Jesús), Troconiz, I.F. (Iñaki F.)   +6 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Critical chain construction with multi-resource constraints based on portfolio technology in South-to-North Water Diversion Project

Water Science and Engineering, 2011
Recently, the critical chain study has become a hot issue in the project management research field. The construction of the critical chain with multi-resource constraints is a new research subject.
Jing-chun Feng, Lei Li, Nan Yang, Yu-zhen Hong, Min Pang, Xiong Yao, Li-cheng Wang   +6 more
doaj   +1 more source

Intrahepatic injection of adenovirus reduces inflammation and increases gene transfer and therapeutic effect in mice [PDF]

, 2006
Recombinant adenoviruses (Ad) are among the most extensively used vectors for liver gene transfer. One of the major limitations for the clinical application of these vectors is the inflammatory immune response associated with systemic administration of ...
Barajas, M. (Miguel), Berraondo, P. (Pedro), Crettaz, J. (Julien), González-Aseguinolaza, G. (Gloria), Hernandez-Alcoceba, R. (Rubén), Kochanek, S. (Stefan), Mauleon, I. (Itsaso), Ochoa, L. (Laura), Prieto, J. (Jesús), Qian, C. (Cheng), Rooijen, N. (Nico) van, Shankar, V. (Vijay)   +11 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Efficacy of intranasal administration of artesunate in experimental cerebral malaria [PDF]

, 2014
BACKGROUND: Improving management of patients suffering from cerebral malaria is needed to reduce the devastating mortality and morbidity of the disease in endemic areas.
Adeline Lavoignat, Anne Marijon, Anne-Lise Bienvenu, Anthony Fourier, Coralie Bringer, Guillaume Bonnot, Marie-Claude Gagnieu, Stéphane Picot   +7 more
core   +2 more sources

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

Oral dosing of rodents using a palatable tablet [PDF]

, 2018
Rationale: Delivering orally bioavailable drugs to rodents is an important component to investigating that route of administration in novel treatments for humans.
AC Mar, AP Brown, Christoffer Bundgaard, D Beracochea, David S. Tait, DC Randall, DC Turner, DM Edgar, Ellen Bowman, ES Robinson, GF Koob, H Bastuji, HL Rowley, HM Murphy, J Duteil, KA Waters, M Bonnichsen, M Touret, MJ Minzenberg, MK Walker, NJ Leith, P Simon, RA Roberts, RE Morgan, Sandeep S. Dhawan, Shuang Xia, T Ishizuka, V Deroche-Gamonet, Verity J. Brown   +28 more
core   +2 more sources

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) Network investigators   +14 more
wiley   +1 more source

Development of Timed Release Vaginal Mucosal Cloprostenol for Farrowing Management in Sows

Pharmaceutics
Background/Objectives: Controlling the timing of farrowing to occur during working hours presents an opportunity to improve supervision and reduce piglet neonatal mortality.
AHM Musleh Uddin, Preechaphon Taechamaeteekul, Kiro R. Petrovski, Padet Tummaruk, Yunmei Song, Sanjay Garg, Roy N. Kirkwood   +6 more
doaj   +1 more source