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Alternative Routes of Administration of Clozapine
CNS Drugs, 2022Clozapine is the only antipsychotic with proven effectiveness in treatment-resistant schizophrenia. It is usually administered using commercially available oral tablets, but not all patients are willing or able to take medicines in this way. Orodispersible clozapine tablets are available from several manufacturers and may be useful where swallowing ...
Siobhan Gee, David Taylor
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Routes of Stem Cell Administration
2022Stem cells are very promising for the treatment of a plethora of human diseases. Numerous clinical studies have been conducted to assess the safety and efficacy of various stem cell types. Factors that ensure successful therapeutic outcomes in patients are cell-based parameters such as source, viability, and number, as well as frequency and timing of ...
S. Fagoonee +5 more
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Nonoral Routes of Estrogen Administration
Obstetrics and Gynecology Clinics of North America, 1987Thus, the effects that a specific estrogen has on the liver is the summation of several mechanisms, including the first pass mechanism and the enhanced delivery of circulating estrogens to this organ. For example, the major estrogen in conjugated estrogen is estrone sulfate.
M I, Cedars, H L, Judd
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The unusual routes of administration
European Journal of Drug Metabolism and Pharmacokinetics, 1996A wide range of administration routes can be drawn on to optimise drug absorption. Though the oral route remains the favourite one for most drugs in many disease states, other routes are routinely used. Each has its strengths and weaknesses and needs to be selected carefully with full consideration of the drug, its target and the release pattern ...
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2009
oral: absorption is most readily with nonionized lipid-soluble drugs (e.g. ethanol), a first-pass effect is observed with some drugs; food can prolong absorption; some drugs (e.g. acetylsalicylic acid, barbiturates, ethanol) decrease gastric emtying; dermal: lipid-soluble drugs are readily absorbed through the skin, reduced blood flow reduces also ...
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oral: absorption is most readily with nonionized lipid-soluble drugs (e.g. ethanol), a first-pass effect is observed with some drugs; food can prolong absorption; some drugs (e.g. acetylsalicylic acid, barbiturates, ethanol) decrease gastric emtying; dermal: lipid-soluble drugs are readily absorbed through the skin, reduced blood flow reduces also ...
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Overview of Routes of IgG Administration
Journal of Clinical Immunology, 2012The use of exogenous serum to provide protection against infections began more than a century ago. Over time, this concept matured and led to the preparation of concentrated immunoglobulin (IgG) products that were safe and effective when delivered subcutaneously (SC) or intramuscularly (IM) but were not ideal for intravenous (IV) use.
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2008
This chapter considers the available routes for systemic administration of analgesic drugs before presenting the evidence for advantage of one route of administration over another for both nonopioid and for opioid analgesic drugs. The techniques of intranasal and inhalation administration of dried plant extracts followed the discovery of tobacco ...
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This chapter considers the available routes for systemic administration of analgesic drugs before presenting the evidence for advantage of one route of administration over another for both nonopioid and for opioid analgesic drugs. The techniques of intranasal and inhalation administration of dried plant extracts followed the discovery of tobacco ...
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A route to de novo domestication of wild allotetraploid rice
Cell, 2021Hong Yu, Tao Lin, Xiangbing Meng
exaly