Results 21 to 30 of about 1,154,427 (304)

The route and timing of hydrogen sulfide therapy critically impacts intestinal recovery following ischemia and reperfusion injury [PDF]

, 2018
PURPOSE: Hydrogen sulfide (H2S) has many beneficial properties and may serve as a novel treatment in patients suffering from intestinal ischemia-reperfusion injury (I/R).
Drucker, Natalie A., Ferkowicz, Michael J., Jensen, Amanda R., Markel, Troy A., te Winkel, Jan P.   +4 more
core   +1 more source

A Physiologically Based Pharmacokinetic Model for Predicting Diazepam Pharmacokinetics after Intravenous, Oral, Intranasal, and Rectal Applications

Pharmaceutics, 2021
Diazepam is one of the most prescribed anxiolytic and anticonvulsant that is administered through intravenous (IV), oral, intramuscular, intranasal, and rectal routes.
Sundus Khalid, Muhammad Fawad Rasool, Imran Imran, Abdul Majeed, Hamid Saeed, Anees ur Rehman, Waseem Ashraf, Tanveer Ahmad, Yousef A. Bin Jardan, Faleh Alqahtani   +9 more
doaj   +1 more source

Exosomes as Naturally Occurring Vehicles for Delivery of Biopharmaceuticals: Insights from Drug Delivery to Clinical Perspectives

Nanomaterials, 2021
Exosomes as nanosized vesicles are emerging as drug delivery systems for therapeutics owing to their natural origin, their ability to mediate intercellular communication, and their potential to encapsulate various biological molecules such as proteins ...
Arun Butreddy, Nagavendra Kommineni, Narendar Dudhipala   +2 more
doaj   +1 more source

Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice [PDF]

, 2019
Background With increasing access to legal cannabis across the globe, it is imperative to more closely study its behavioral and physiological effects.
Boehm, Stephen L., II, Lapish, Christopher C., Mackie, Ken, Smoker, Michael P.   +3 more
core   +2 more sources

Current Strategies and Potential Prospects for Nanoparticle-Mediated Treatment of Diabetic Nephropathy

Diabetes, Metabolic Syndrome and Obesity, 2022
Chunkang Liu,1,* Kunzhe Wu,2,* Huan Gao,3 Jianyang Li,3 Xiaohua Xu3 1Department of Gastrointestinal Surgery, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Scientific Research Center, China ...
Liu C, Wu K, Gao H, Li J, Xu X
doaj  

Stem cell therapy in neurological disorders: promises and concerns

Exploration of Neuroprotective Therapy, 2023
Self-neuronal regeneration is often limited or nonexistent after neuronal cell damage, making new technologies necessary for treating neurological damage.
Said Hachimi-Idrissi
doaj   +1 more source

Immunogenicity and safety of intramuscular versus subcutaneous administration of a combined measles, mumps, rubella, and varicella vaccine to children 12 to 18 months of age

Human Vaccines & Immunotherapeutics, 2019
This randomized trial conducted in France compared intramuscular (IM) and subcutaneous (SC) administration of two doses of a measles, mumps, rubella, and varicella (MMRV) combination vaccine (ProQuad®) administered one month apart to 405 children 12–18 ...
Hervé Haas, Patrick Richard, Cécile Eymin, Anne Fiquet, Barbara Kuter, Benoit Soubeyrand   +5 more
doaj   +1 more source

A preclinical model of THC edibles that produces high-dose cannabimimetic responses

eLife
No preclinical experimental approach enables the study of voluntary oral consumption of high-concentration Δ9-tetrahydrocannabinol (THC) and its intoxicating effects, mainly owing to the aversive response of rodents to THC that limits intake.
Anthony English, Fleur Uittenbogaard, Alexa Torrens, Dennis Sarroza, Anna Veronica Elizabeth Slaven, Daniele Piomelli, Michael R Bruchas, Nephi Stella, Benjamin Bruce Land   +8 more
doaj   +1 more source

Patient Perception of Route of Rectal Administration of Live Biotherapeutic Product for Recurrent Clostridioides difficile Infection

Patient Preference and Adherence, 2023
Paul Feuerstadt,1,2 Caterina Oneto,3,4 Glenn Tillotson,5 Nicholas W Van Hise6 1Division of Digestive Disease, Yale School of Medicine, New Haven, CT, USA; 2PACT Gastroenterology Center, Hamden, CT, USA; 3Department of Medicine, New York University ...
Feuerstadt P, Oneto C, Tillotson G, Van Hise NW   +3 more
doaj  

Immunogenicity and safety of concomitant administration of a measles, mumps and rubella vaccine (M-M-RvaxPro) and a varicella vaccine (VARIVAX) by intramuscular or subcutaneous routes at separate injection sites: a randomised clinical trial [PDF]

, 2009
Background When this trial was initiated, the combined measles, mumps and rubella (MMR) vaccine was licensed for subcutaneous administration in all European countries and for intramuscular administration in some countries, whereas varicella vaccine was ...
Yves Gillet, Pirmin Habermehl, Stéphane Thomas, Cécile Eymin, Anne Fiquet, AA Gershon, SG Baum, AA Gershon, U Heininger, F Zhou, H Peltola, M Böttiger, Centers for Disease Control and Prevention, AO Jumaan, HQ Nguyen, WHO Europe, Centers for Disease Control and Prevention, G Rasch, J Ramet, N Sengupta, V Usonis, SA Plotkin, MR Hilleman, SA Wyll, MR Hilleman, JE Lewis, J Stokes Jr, PJ Landrigan, S Li, RE Weibel, CJ White, M Vázquez, B Kuter, JF Seward, The National Vaccine Advisory Committee, HR Shinefield, PM Keller, EH Wasmuth, PJ Provost, O Miettinen, Y Hochberg, PH Dennehy, RP Wise   +42 more
core   +1 more source