Results 51 to 60 of about 1,154,427 (304)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Inhaled insulin: overview of a novel route of insulin administration

Vascular Health and Risk Management, 2010
Lucy D MastrandreaDepartment of Pediatrics, School of Medicine and Biochemical Sciences, University at Buffalo, Buffalo, NY, USAAbstract: Diabetes is a chronic disease characterized by inadequate insulin secretion with resulting hyperglycemia.
Lucy D Mastrandrea
doaj  

Cannabis use frequency, route of administration, and co-use with alcohol among older adults in Washington state

Journal of Cannabis Research, 2021
Background The US national surveys and data from legal adult use cannabis states show increases in the prevalence of cannabis use among older adults, though little is known about their manner of cannabis consumption.
Meenakshi S. Subbaraman, William C. Kerr
doaj   +1 more source

Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice

Molecular Metabolism, 2022
Objective: The glucose tolerance test (GTT) is widely used in preclinical research to investigate glucose metabolism, but there is no standardised way to administer glucose. The aim of this study was to directly compare the effect of the route of glucose
Lewin Small, Amy Ehrlich, Jo Iversen, Stephen P. Ashcroft, Kajetan Trošt, Thomas Moritz, Bolette Hartmann, Jens J. Holst, Jonas T. Treebak, Juleen R. Zierath, Romain Barrès   +10 more
doaj   +1 more source

Clinical and cost impact of intravenous proton pump inhibitor use in non-ICU patients [PDF]

, 2015
AIM: To assess the appropriateness of the indication and route of administration of proton-pump-inhibitors (PPIs) and their associated cost impact. METHODS: Data collection was performed prospectively during a 6-mo period on 340 patients who received ...
Dimassi, Hani I., Nasser, Soumana C., Nassif, Jeanette G.   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Snake Antivenoms—Toward Better Understanding of the Administration Route

Toxins, 2023
Envenomations induced by animal bites and stings constitute a significant public health burden. Even though a standardized protocol does not exist, parenterally administered polyclonal antivenoms remain the mainstay in snakebite therapy.
Erika Gamulin, Sanja Mateljak Lukačević, Beata Halassy, Tihana Kurtović   +3 more
doaj   +1 more source

A comparison of medetomidine and its active enantiomer dexmedetomidine when administered with ketamine in mice [PDF]

, 2013
Medetomidine-ketamine (MK) and dexmedetomidine-ketamine (DK) are widely used to provide general anaesthesia in laboratory animals, but have not been compared directly in many of these species, including rodents.
Burnside, Wesley M., Cameron, Angus I, Flecknell, Paul A., Thomas, Aurélie A   +3 more
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The knowledge of patients referred to Kerman pharmacies about their dispensed drugs, 1997

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2001
Objective: Correct and rational use of drugs is one of the main factors in successful treatment and the patient should be aware of this dispensed drugs. This study was carried out to evaluate the knowledge of patients referred to Kerman pharmacies about ...
Ch Sepehri, S Kohan, Z Ghazanfari
doaj