Results 61 to 70 of about 1,154,427 (304)

Toxicokinetics of fumonisin B1 in turkey poults and tissue persistence after exposure to a diet containing the maximum European tolerance for fumonisins in avian feeds [PDF]

, 2008
The kinetic of fumonisin B1 (FB1) after a single IV and oral dose, and FB1 persistence in tissue were investigated in turkey poults by HPLC after purification of samples on columns.
Bailly, Jean Denis, Grosjean, François, Guerre, Philippe, Skiba, Fabien, Tardieu, Didier   +4 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Position Statement on Route Five and the Peace Bridge [PDF]

, 2008
The Partnership for the Public Good rejects the Department of Transportation, the Public Bridge Authority, and the Federal Highway Administration\u27s \u27preferred alternatives\u27, in favor of the community\u27s preferred alternatives for Peace Bridge ...

core   +1 more source

Influence of the Compaction Pressure and Sintering Temperature on the Mechanical Properties of Porous Titanium for Biomedical Applications [PDF]

, 2019
In the present work, the use of porous titanium is proposed as a solution to the difference in stiffness between the implant and bone tissue, avoiding the bone resorption.
Castillo, Sandra M., Díaz, Eduardo, Muñoz Moreno, Sergio, Torres Hernández, Yadir, Trueba Muñoz, Paloma   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Randomized crossover pharmacokinetic evaluation of subcutaneous versus intravenous granisetron in cancer patients treated with platinum-based chemotherapy [PDF]

, 2007
BACKGROUND: 5-HT3-receptor antagonists are one of the mainstays of antiemetic treatment, and they are administered either i.v. or orally. Nevertheless, sometimes neither administration route is feasible, such as in patients unable to admit oral intake
Azanza, J.R. (José Ramón), Blanco-Prieto, M.J. (María José), Cabello, J.P. (J.P.), Campanero, M.A. (Miguel Angel), Ceballos-Viro, J. (Jaime), Cruz, S. (S.) de la, Fernandez-Gallego, V. (V.), Garcia-Foncillas, J. (Jesús), Gil-Aldea, I. (I.), Gurpide, A. (Alfonso), Lopez-Picazo, J.M. (José M.), Martin-Algarra, S. (Salvador), Olier, C. (Clara), Perez-Gracia, J.L. (Jose Luis), Reyna, C. (Carmen), Sadaba, B. (Belén)   +15 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Examining patient preferences in the treatment of rheumatoid arthritis using a discrete-choice approach [PDF]

, 2016
Background: Biological disease-modifying antirheumatic drugs (bDMARDs) used in second-line treatment of rheumatoid arthritis (RA) are administered parenterally.
Alten, Rieke, Behmer, Olaf, Krüger, Klaus, Nolting, Hans-Dieter, Rellecke, Julian, Schiffhorst, Guido, Schiffner-Rohe, Julia   +6 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Mode matters: exploring how modes of cannabis administration affect THC plasma concentrations and subjective effects

Journal of Cannabis Research
As cannabis products become increasingly accessible and novel modes of administration like dabbing and vaping gain popularity, understanding how these modes impact use experiences and abuse liability is crucial.
Margy Y. Chen, Ashley Brooks-Russell, Angela D. Bryan, L. Cinnamon Bidwell   +3 more
doaj   +1 more source