Results 81 to 90 of about 1,154,427 (304)

Spatial Distribution of (R)-salbutamol in Rat Brain Following Nasal and Intravenous Administration Using DESI-MS

Pharmaceutics, 2020
Recent studies have shown that β2-Adrenoreceptor is a regulator of the a-synuclein gene driving risk of Parkinson’s disease. The β2-AR agonist (R)-salbutamol, eutomer of rac-salbutamol, may hold therapeutic potential for Parkinson’s
Rui Zhang, Jie Wu, Siyu Liu, LiangJun Deng, Junhua Hu, Xi Chen, Wen Tan   +6 more
doaj   +1 more source

Drug vaping applied to cannabis: Is "Cannavaping" a therapeutic alternative to marijuana? [PDF]

, 2016
Therapeutic cannabis administration is increasingly used in Western countries due to its positive role in several pathologies. Dronabinol or tetrahydrocannabinol (THC) pills, ethanolic cannabis tinctures, oromucosal sprays or table vaporizing devices are
Augsburger, M., Berthet, Aurélie, Concha-Lozano, Nicolas, De Cesare, M., Favrat, B., Giroud, C., Lauer, E., Plateel, Gregory, Thomas, A., Varlet, V.   +9 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Stability or versatility: transitions in fentanyl routes of administration

Harm Reduction Journal
Background Transitions in how people use drugs have long influenced drug use research and the policy landscape. In unregulated drug markets, route of administration (ROA) transitions from injecting opioids to non-injecting modes of use, sometimes called ...
Jeff Ondocsin, Sarah G. Mars, Nicole Holm, Allison Schlosser, Jason Fessel, Amanda Cowan, Michael Duke, Daniel Ciccarone   +7 more
doaj   +1 more source

Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia [PDF]

, 2002
Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage.
Alvarez, Dalia, Candelario-Jalil, Eduardo, Garcia-Cabrera, Michel, Giuliani, Attilia, Gonzalez-Falcon, Armando, Leon, Olga S., Martinez-Sanchez, Gregorio, Merino, Nelson   +7 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Characteristics of pediatric interventional drug trials registered between 2015 and 2024 on ClinicalTrials.gov

Frontiers in Pediatrics
AimThis study comprehensively analyzed the characteristics and development trends of pediatric interventional drug clinical trials registered between 2015 and 2024, with a focus on pharmaceutical characteristics such as dosage form and administration ...
Yinghong Zhou, Zhaoxin Liu, Ji Xu, Ying Zhang, Haiqi Shen, Siyu Jiang, Yunyun Shi, Yinghua Lv, Jihan Huang   +8 more
doaj   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Review on Utharavasthi (Urogenital route of medicine administration)

Journal of Research in Traditional Medicine, 2018
Background: Vasthi (Rectal/urogenital route of medicine administration) is one among the most important therapies among the Panchakarma ( five purification therapy). Susrutha Acharya describes Vasthi as effective in disorders due to derangement of Vatha,
Meghana Pooleriveetil Padikkal
doaj   +1 more source

Relapsing-remitting multiple sclerosis: advances in disease-modifying therapies [PDF]

, 2015
Multiple sclerosis is a demyelinating disease affecting the central nervous system. It is the most prevalent disabling neurological condition among young adults, with onset typically between 20 and 40 years of age. Infiltrating immune cells and microglia
Kay, Kathleen Alexandra
core   +1 more source