Results 91 to 100 of about 648,399 (346)

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

Exercise Interventions in Children, Adolescents and Young Adults With Paediatric Bone Tumours—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser, Claire Laurie, Teresa Schmidt, Irene von Luettichau, Peter Bekkering, Sabine Kesting   +5 more
wiley   +1 more source

Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients. [PDF]

, 2018
In December 2017, the National Academy of Neuropsychology convened an interorganizational Summit on Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients in Denver, Colorado. The Summit brought together representatives of a
Adler, Deb, Alban, Christopher, Bondi, Mark, Braun, Michelle, Cagigas, Xavier, Daven, Morgan, Denney, Robert L, Drozdick, Lisa, Foster, Norman L, Golden, Tamara, Hwang, Ula, Iverson, Grant, Ivey, Laurie, Kramer, Joel, Lacritz, Laura, Lantz, Melinda, Latts, Lisa, Ling, Shari M, Malone, Michael, Maria Lopez, Ana, Martin-Plank, Lori, Maslow, Katie, McConnel, Charles E, Melady, Don, Messer, Melissa, Meyers, John, Most, Randi, Norris, Margaret P, Perry, William, Pliskin, Neil, Roebuck-Spencer, Tresa, Shafer, David, Silver, Cheryl, Silverberg, Nina, Thomas, Colin M, Thornhill, Laura, Tsai, Jean, Vakharia, Nirav, Waters, Martin   +38 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Testing for ARCH in the Presence of Nonlinearity of Unknown Form in the Conditional Mean [PDF]

Tests of ARCH are a routine diagnostic in empirical econometric and financial analysis. However, it is well known that misspecification of the conditional mean may lead to spurious rejections of the null hypothesis of no ARCH.
Andrew P. Blake, George Kapetanios
core  

Early and Differential Diagnosis of Dementia and Mild Cognitive Impairment Design and Cohort Baseline Characteristics of the German Dementia Competence Network [PDF]

, 2009
Background: The German Dementia Competence Network (DCN) has established procedures for standardized multicenter acquisition of clinical, biological and imaging data, for centralized data management, and for the evaluation of new treatments.
Frölich, Lutz, Gertz, Hermann-Josef, Hampel, Harald, Henn, Fritz, Heuser, Isabella, Huell, Michael, Jahn, Holger, Jessen, Frank, Kornhuber, Johannes, Luckhaus, Christian, Maier, Wolfgang, Pantel, Johannes, Perneczky, Robert, Peters, Oliver, Rienhoff, Otto, Ruüther, Eckart, Schmidtke, Klaus, Schroeder, Johannes, Seuchter, Susanne A., Weih, Markus, Wiltfang, Jens, Wolf, Stefanie   +21 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Performance of Xpert MTB/RIF and acid-fast bacilli smear microscopy for the diagnosis of pulmonary tuberculosis using bronchoalveolar lavage samples in negative or sputum-scarce adults in Colombia: a retrospective diagnostic accuracy study

BMC Infectious Diseases
Background Limited literature exists on the diagnostic yield of traditional and molecular tuberculosis (TB) tests using bronchoalveolar lavage (BAL) specimens in high burden South American countries. The aim of the study is to determine the value of acid-
Vanessa Sabella-Jiménez, Valentina L. Sabella-Jiménez, Valentina Restrepo-Espinosa, Juanita Eljadue-Flórez, Claredit Valentina Gallardo-Castro, Andrea Alexandra Silvera, Carlos Otero-Herrera, Hugo Andrés Macareno Arroyo, Jorge Acosta-Reyes, Jorge Luis Quintero Barrios   +9 more
doaj   +1 more source

Further investigation of confirmed urinary tract infection (UTI) in children under five years: a systematic review. [PDF]

, 2005
Background: Further investigation of confirmed UTI in children aims to prevent renal scarring and future complications. Methods: We conducted a systematic review to determine the most effective approach to the further investigation of confirmed urinary ...
A Biggi, A Fretzayas, A Gervaix, A Haberlik, A Hitzel, A Hitzel, A Piepsz, AL Valentini, AR Bergius, B Boudailliez, B Jakobsson, B Mucci, BA Jantausch, BP Barry, C Antachopoulos, C De Sadeleer, C Prat, C Radmayr, D Baronciani, D Benador, D Landau, D Landau, D Morin, D Siamplis, DJ Roebuck, E Stokland, E Stokland, E Stokland, ED Evans, F Castello Girona, F Guermazi, FE Pickworth, G Alzen, G Capa Kaya, G Krzemien, G Piaggio, G Zamir, GA McLorie, GN Sfakianakis, GW LeQuesne, HC Scherz, HJ Mentzel, I Gordon, I Gordon, Ian S Watt, IG Verber, J Larcombe, J Stock, J Winberg, JG Lijmer, JL Fleiss, Jos Kleijnen, JR MacKenzie, Julie Cooper, K Everaert, K Mage, K Schneider, L Von Rohden, LE Moses, M el Hajjar, M Hellstrom, M Ilyas, M Nakamura, M Salih, M Uhl, M Wennerstrom, M Wennerstrom, Marie E Westwood, MD Muro, MP Andrich, MP Lavocat, MR Ditchfield, MV Merrick, N Buyan, N Le Saux, OJ Muensterer, P Whiting, Penny F Whiting, PJ Hedman, PT Dick, PT Dick, R DerSimonian, R Oostenbrink, RF Galbraith, RL McEwing, RM Kessler, S Bykov, S Jequier, S Mahant, SH Sacks, SJ Vernon, SM Tan, T Berrocal, T Berrocal Frutos, T Dura Trave, U Alon, V Smolkin, V Sreenarasimhaiah, WH Foresman, Working Group of the Research Unit of the Royal College of Physicians, ZE Bircan   +100 more
core   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source