Results 71 to 80 of about 592,995 (349)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Overnight Dexamethasone Suppression Test in the Diagnosis of Cushing's Disease

Acta Medica Iranica, 2010
Realizing the cause of Cushing's Syndrome (CS) is one of the most challenging processes in clinical endocrinology. The long high dose dexamethasone suppression test (standard test) is costly and need an extended inpatient stay.
Fatemeh Esfahanian, Rozana Kazemi
doaj  

Diagnostic accuracy and clinical impact of MRI-based technologies for patients with non-alcoholic fatty liver disease: systematic review and economic evaluation

Health Technology Assessment, 2023
Background Magnetic resonance imaging-based technologies are non-invasive diagnostic tests that can be used to assess non-alcoholic fatty liver disease. Objectives The study objectives were to assess the diagnostic test accuracy, clinical impact and cost-
Bresnahan Rebecca, Duarte Rui, Mahon James, Beale Sophie, Chaplin Marty, Bhattacharyya Devarshi, Houten Rachel, Edwards Katherine, Nevitt Sarah, Maden Michelle, Boland Angela   +10 more
doaj   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Effectiveness of professional and patient-oriented strategies in reducing vitamin D and B12 test ordering in primary care: a cluster randomised intervention study

BJGP Open, 2021
Background: Vitamin tests are increasingly ordered by GPs, but a clinical and evidence-based indication is often lacking. Harnessing technology (that is, decision support tools and redesigning request forms) have been shown to reduce vitamin requests ...
Saskia van Vugt, Evelien de Schepper, Sanne van Delft, Nicolaas Zuithoff, Niek de Wit, Patrick Bindels   +5 more
doaj   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Reliability of Rapid Diagnostic Tests in Diagnosing Pregnancy-Associated Malaria in North-Eastern Tanzania. [PDF]

, 2012
Accurate diagnosis and prompt treatment of pregnancy-associated malaria (PAM) are key aspects in averting adverse pregnancy outcomes. Microscopy is the gold standard in malaria diagnosis, but it has limited detection and availability.
A Mayor, A Moody, A Muehlenbachs, A Salanti, AA Adegnika, Adrian JF Luty, AE Mnzava, AHD Kilian, AJ Umbers, Ali Salanti, AM de Oliveira, B Mmbando, C Wongsrichanalai, Caroline Pehrson, CE Shulman, CE Shulman, Christentze Schmiegelow, D Ishengoma, Daniel Andersen, Daniel TR Minja, Davis John, DP Mason, DR Bell, DRS Ishengoma, E Tjitra, F Bánhidy, F Mockenhaupt, FP Mockenhaupt, FP Mockenhaupt, G Snounou, H Reyburn, H Verhoef, HL Guyatt, IA McGregor, J Baker, J Lusingu, J Wooden, JM Tham, John PA Lusingu, JP Lusingu, JR Forney, K Källander, KA Bojang, LC Okell, LEG Mboera, LM Singer, M Amexo, M Dhorda, M Fried, M Fried, M Mayxay, M Mayxay, Martha Lemnge, Mayke Oesterholt, Michael Alifrangis, ML McMorrow, N Othnigué, NEER Singh, NJ White, P Bejon, P Mens, P Mens, Pamela A Magistrado, PE Duffy, Philippe Deloron, R Bǿdker, RW Steketee, S Gerstl, S Karl, S Schachterle, Stéphanie Boström, T Jelinek, TA VanderJagt, The United Republic of Tanzania, Thor Theander, TT Thomsen, V Batwala, WHO   +77 more
core   +2 more sources

Application of Ultrasonography and Radiography in Detection of Hemothorax: a Systematic Review and Meta-Analysis

Emergency, 2016
Introduction: Hemothorax is one of the most prevalent injuries caused by thoracic traumas. Early detection and treatment of this injury is of utmost importance in prognosis of the patient, but there are still controversial debates on the diagnostic value
Vafa Rahimi-Movaghar, Mahmoud Yousefifard, Parisa Ghelichkhani, Masoud Baikpour, Abbas Tafakhori, Hadi Asady, Gholamreza Faridaalaee, Mostafa Hosseini, Saeed Safari   +8 more
doaj  

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source