Results 81 to 90 of about 592,995 (349)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

The future of laboratory medicine - A 2014 perspective. [PDF]

, 2015
Predicting the future is a difficult task. Not surprisingly, there are many examples and assumptions that have proved to be wrong. This review surveys the many predictions, beginning in 1887, about the future of laboratory medicine and its sub ...
FORTINA, PAOLO, Kricka LJ, Park JY, Polsky TG   +3 more
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

The differential diagnosis of Huntington's disease-like syndromes: 'red flags' for the clinician [PDF]

, 2013
A growing number of progressive heredodegenerative conditions mimic the presentation of Huntington's disease (HD). Differentiating among these HD-like syndromes is necessary when a patient with a combination of movement disorders, cognitive decline ...
Bhatia, KP, Martino, D, Stamelou, M
core  

Global burden of human brucellosis : a systematic review of disease frequency [PDF]

, 2012
BACKGROUND: This report presents a systematic review of scientific literature published between 1990-2010 relating to the frequency of human brucellosis, commissioned by WHO.
A El Sherbini, A Yacoub, AA Haghdoost, Anna S. Dean, B Bonfoh, B Hernandez, E Jelastopulu, E Schelling, Esther Schelling, F De Massis, F Roth, FK Al-Ani, G Marder, G Pappas, GJ Jennings, Helena Greter, Hélène Carabin, I Avdikou, J Ariza, J Zinsstag, J Zinsstag, JA Al Tawfiq, JA Crump, Jakob Zinsstag, KE Elbeltagy, Lisa Crump, M Minas, MA Al Sekait, MA Idris, MR Hosseini, MR Khorasgani, N Gargouri, O Karabay, QM Abu Shaqra, R Awad, S Vancelik, SA Dahouk, SM Alavi, SR Alballa, TJ Doyle, Z Cetinkaya   +40 more
core   +4 more sources

Comparison of Ultrasonography and Radiography in Detection of Thoracic Bone Fractures; a Systematic Review and Meta-Analysis

Emergency, 2016
Introduction: The potential benefit of ultrasonography for detection of thoracic bone fractures has been proven in various surveys but no comprehensive conclusion has been drawn yet; therefore, the present study aimed to conduct a thorough meta-analytic ...
Mahmoud Yousefifard, Masoud Baikpour, Parisa Ghelichkhani, Hadi Asady, Abolfazl Darafarin, Mohammad Reza Amini Esfahani, Mostafa Hosseini, Mehdi Yaseri, Saeed Safari   +8 more
doaj  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Prostatic Acid Phosphatase: A Potpourri [PDF]

, 1973
I would first like to discuss this enzyme, reviewing some of its chemistry, its clinical value and the pitfalls and problems associated with the routine tests.
Moncure, Charles W.
core   +1 more source

MISSED: an environment for mixed-signal microsystem testing and diagnosis [PDF]

, 1993
A tight link between design and test data is proposed for speeding up test-pattern generation and diagnosis during mixed-signal prototype verification. Test requirements are already incorporated at the behavioral level and specified with increased detail
Docherty, G., Kerkhoff, H.G.
core   +3 more sources

Admission dental examination: protocol and its importance in the diagnosis of oral pathology

Brazilian Journal of Oral Sciences, 2015
The aim of this paper is to describe an efficient clinical protocol used in admittance dental examinations, highlighting the importance of this evaluation in the diagnosis of oral pathologies.
Mário Marques Fernandes, Mara Rosângeles de Oliveira, Rafael Bender Carpena de Menezes de Oliveira, Talita Lima de Castro, Luiz Renato Paranhos, Eduado Daruge Júnior   +5 more
doaj   +1 more source