Results 51 to 60 of about 44,409 (306)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

A novel energy-aware routing protocol in intermittently connected delay-tolerant wireless sensor networks

open access: yesInternational Journal of Distributed Sensor Networks, 2017
In delay-tolerant wireless sensor networks, messages for sensor data are delivered using opportunistic contacts between intermittently connected nodes. Since there is no stable end-to-end routing path like the Internet and mobile nodes operate on battery,
Min Wook Kang, Yun Won Chung
doaj   +1 more source

Design of MANET Routing Based on Node Stability and Cross-layer Optimization [PDF]

open access: yesJisuanji gongcheng, 2017
Aiming at the problem of poor routing stability and high end-to-end delay in the Optimized Link State Routing(OLSR) protocol in Mobile Ad-hoc Network(MANET),an improved OLSR routing protocol is proposed.In view of the mobility characteristic of the MANET
SHEN Weiyang,LIU Qiang,OUYANG Feng
doaj   +1 more source

Weight-Based PA-GPSR Protocol Improvement Method in VANET

open access: yesSensors, 2023
Vehicle Ad-hoc network (VANET) can provide technical support and solutions for the construction of intelligent and efficient transportation systems, and the routing protocol directly affects the efficiency of VANET. The rapid movement of nodes and uneven
Wenzhu Zhang   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Energy-aware peering routing protocol for indoor hospital body area network communication

open access: yes, 2012
The recent research in Body Area Networks (BAN) is focused on making its communication more reliable, energy efficient, secure, and to better utilize system resources.
Aslam, Nauman   +3 more
core   +1 more source

Performance Analysis of DTN Using Level Signal Priority Epidemic Routing Protocol

open access: yesEmitter: International Journal of Engineering Technology, 2016
A DTN architecture consists of several nodes that are connected with high dynamic topology. The routing protocol is an important part which determine the DTN performance system.
Ahmad Zainudin   +2 more
doaj   +3 more sources

ANALISIS PERBANDINGAN ROUTING PROTOKOL OPEN SHORTES PATH FIRST (OSPF) DENGAN ENHANCED INTERIOR GATEWAY ROUTING PROTOCOL (EIGRP)

open access: yesIlkom Jurnal Ilmiah, 2018
Routing adalah proses pemilihan rute terbaik untuk suatu paket data agar dapat sampai ke tujuannya. Proses routing sangat dibutuhkan dalam proses pengiriman  data.
Nur Indah, Yulita Salim, Ramdan Satra
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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