Results 191 to 200 of about 781,525 (281)

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Whole orchard recycling in California's Central Valley: Benefits, management, and adoption. [PDF]

J Environ Qual
Culumber CM, Holtz B, Gao S, Poret-Peterson A, Thao T, Zuber C, Niederholzer F, Yaghmour M, Camarena-Onofre D, Rivers D, Browne G, Halleck BT.   +11 more
europepmc   +1 more source

From Sensing Mechanisms to System Co‐Design: Graphene‐Based Sensors and Readout Circuits

Advanced Science, EarlyView.
This review establishes a unified PS–EQ–RF framework linking graphene sensing mechanisms, native electrical outputs, and output‐specific readout circuits. Voltage‐, current‐, resistance‐, and capacitance‐type sensing systems are systematically classified to guide architecture selection, low‐noise design, system co‐design, and practical integration ...
Jinduo Zhang, Meng Chen, Guanchen Li, Ruifeng Liu, Yingxin Wang, Ziran Zhao   +5 more
wiley   +1 more source

A multi-environment dataset consisting of official field trials for three major crops in the Nordic countries. [PDF]

Sci Data
Aasen NR, Herrera-Foessel SA, Vandeskog SM, Bengtsson T, Dida MG, Drozdik I, Dalmannsdottir S, Gautason E, Grodek JS, Hilmarsson HS, Högnäsbacka M, Jäck O, Kaseva J, Laine A, Lenkoski A, Lillemo M, Lin M, Lundby AM, Mohammadi S, Møllerhagen PJ, Niskanen M, Ortiz R, Skalshøi M, Þórðardóttir AG, Thorkildsen M, NordBalFoodSec consortium.   +25 more
europepmc   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Effect of Fertilization and Row Spacing on the Performance of Nettle (<i>Urtica dioica</i> L.) Under Mediterranean Conditions. [PDF]

Plants (Basel)
Mavroeidis A, Stavropoulos P, Roussis I, Karydogianni S, Papadopoulos G, Kallergi S, Chatzitriantafyllou M, Pachi V, Beslemes D, Tigka E, Kakabouki I, Bilalis D.   +11 more
europepmc   +1 more source

Supercapacitor Safety: Overcharge‐Induced Failure Mechanisms in Electrochemical Double‐Layer Capacitors

Advanced Science, EarlyView.
Time‐resolved synchrotron radiography reveals the internal evolution of electrochemical double‐layer capacitors under abusive overcharge. EDLCs are shown to follow a thermally driven failure pathway involving electrolyte decomposition, gas generation, and structural collapse, distinct from chemically driven thermal runaway effects of Lithium‐ion ...
Thomas Dore, Inez Kesuma, Abdus S. Ali, Jonas Pfaff, Yuxiao Jin, Rosalie Hamill, Mark Buckwell, Hamish Reid, Thomas Finco, Zeyu Sun, Yuanze Li, Sebastian Schopferer, Siegfried Nau, Nils Böttcher, Henning Markötter, Alexander J. E. Rettie, James Robinson, Paul R. Shearing, Alexander Rack, Thomas S. Miller   +19 more
wiley   +1 more source

Yield Performance, Resource-Use Efficiency, and Economic Profitability from Adopting Soybean-Based Cotton/Maize/Sugarcane Intercropping Systems Under Arid-Irrigated Conditions. [PDF]

Plants (Basel)
Yasin HS, Raza MA, Feng L, Han J.
europepmc   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Living cover crops are associated with higher earthworm abundance and biomass in a subtropical citrus orchard. [PDF]

Front Plant Sci
Zeng C, Li Z, Tang H, Su L, Su T, Yu Y, Liang H, Dong W, Wei C, He T.   +9 more
europepmc   +1 more source