Results 21 to 30 of about 559,892 (275)
npj Parkinson's Disease, 2023 Terazosin is an α1-adrenergic receptor antagonist that enhances glycolysis and increases cellular ATP by binding to the enzyme phosphoglycerate kinase 1 (PGK1). Recent work has shown that terazosin is protective against motor dysfunction in rodent models
Matthew A. Weber +7 more
doaj +1 more source
Histone deacetylase 10 structure and molecular function as a polyamine deacetylase
Nature Communications, 2017 Polyamines bind to nucleic acids and their function is regulated by reversible acetylation. Here, the authors show that histone deacetylase 10 is a polyamine deacetylase and present its crystal structure with a bound polyamine transition state analogue ...
Yang Hai +3 more
doaj +1 more source
TEORIA DA ADAPTAÇÃO E SAÚDE DO TRABALHADOR EM HOME OFFICE NA PANDEMIA DE COVID-19
Revista Baiana de Enfermagem, 2020 Objetivo: refletir sobre as implicações do trabalho em Home Office no período da pandemia de COVID-19 na saúde dos indivíduos, sob a perspectiva da Teoria da Adaptação desenvolvida por Callista Roy.
Nathalia Henriques Veiga +5 more
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Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
Proyección, 2021 Hace 100 años, en 1921, se conocieron Pierre Teilhard de Chardin y Édouard Le Roy. De la amistad entre ellos sabemos mucho por la correspondencia que se extendíó durante 25 años, desde 1921 a 1946.
Leandro Sequeiros San Román
doaj
CHARACTERIZATION OF UNIVARIATE LONG-TERM URBAN INTERNET TRAFFIC VOLUME
ICTACT Journal on Communication Technology, 2017 The proposed work deals with a real time hourly internet traffic data set in bits collected from ISPs located in 11 cities of European Country for the period 7th June 2005 to 31st July 2005.
Subhasish Debroy +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub +24 more
wiley +1 more source
Trajectoires, 2020 Le passage d’un pouvoir temporel séparé du pouvoir spirituel à une forme protestante de double pouvoir avec la sacralité du prince chef de son Église semble s’être fait dans l’urgence du contexte de la rupture de Luther avec la papauté romaine. L’article examine en détail comment cette nouvelle combinaison des deux pouvoirs trouve ses racines dans la ...
openaire +3 more sources
Scientific ReportsAyurveda, a traditional Indian system of medicine, advocates the use of processed Plumbago zeylanica L. roots for managing inflammatory and rheumatic conditions. However, scientific evidence supporting its anti-arthritic potential remains unexplored. Our
Tanmoy Das +5 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among patients receiving long‐term HCQ with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain optical coherence tomography (SD‐OCT) for screening ...
Narsis Daftarian +4 more
wiley +1 more source