Results 111 to 120 of about 639,063 (347)

An Appointed Upper House: Lessons from Canada [PDF]

open access: yes, 1998
The abolition of hereditary peers' rights will leave the UK with a wholly appointed transitional upper house. The second stage will be decided only after a Royal Commission has reported.
Russell, M
core  

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

open access: yesAdvanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang   +12 more
wiley   +1 more source

Rapid Decentralized Prostate Cancer Risk Stratification by Portable Liquid Biopsy Analysis within a Clinical Biosensor Validation Framework

open access: yesAdvanced Science, EarlyView.
In this work, we showcased two significant scientific advances in (i) developing a portable biosensor technology for rapid decentralized prostate cancer urinary biomarker testing and reporting, with superior performance to current clinical testing practice; and (ii) proposing a clinical validation framework (for our biosensor development) which can be ...
Kevin M. Koo   +14 more
wiley   +1 more source

Assessing the different dimensions and degrees of risk of child sexual abuse in institutions [PDF]

open access: yes, 2017
This research report has been published by the Royal Commission into Institutional Responses to Child Sexual Abuse. It identifies four dimensions of risk of child sexual abuse in institutional settings: situational, vulnerability, propensity and ...
Cashmore, J., Parkinson, P.
core  

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

open access: yesAdvanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei   +10 more
wiley   +1 more source

Non-operative management of a rare late gastrocolic fistula after percutaneous endoscopic gastrostomy in pediatrics

open access: yesJournal of Pediatric Surgery Case Reports
Introduction: Gastrocolic fistula is a rare but serious complication of percutaneous endoscopic gastrostomy (PEG). Case presentation: A 13-year-old male with quadriplegic cerebral palsy and a PEG inserted two years prior presented with a one-month ...
Medhat elsayed   +5 more
doaj   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló   +2 more
wiley   +1 more source

Fit for a Royal Commission?

open access: yesThe Rijksmuseum Bulletin, 2015
Aleksandra Lipin´ska
doaj   +1 more source

Nicholas Fuller against the High Commission, the Ex Officio Oath and in Defence of the Priviledge not to Incriminate Oneself

open access: yesИзвестия Уральского федерального университета. Серия 2: Гуманитарные науки
This article describes the early seventeenth-century litigation of lawyer Nicholas Fuller against the ecclesiastical tribunal of the High Commission. Based on court records, parliamentary proceedings, and the treatise written by the counsel, the article ...
Sergey Vitalievich Kondratiev
doaj   +1 more source

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