Results 41 to 50 of about 14,454,620 (235)

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

CMS RPC activities during LHC LS-2 [PDF]

, 2020
The second LHC long shutdown period (LS2) is an important opportunity for the CMS Resistive Plate Chambers (RPC) to complete their consolidation and upgrade projects.
Park J., Singh J., De Souza S. F., Di Crescenzo A., Petrov A., Fienga F., De Jesus Damiao D., Combaret C., Saviano G., Elmetenawee W., Laktineh I., Iaselli G., Piccolo D., Fraga J., Lomidze I., Zaganidis N., Lista L., Shah M. A., Shchablo K., De Filippis N., Tytgat M., Assran Y., Hoorani H., Nogima H., Riccardi C., Buontempo S., Gouzevitch M., Hong B., Ramos D., Kim T. J., Mahmoud M. A., Caponero M., Passamonti L., Salvini P., Samalan A., Zareian E., Elsayed S., Sanchez G. A. A., Mohammed Y., Paolucci P., Qian S. J., Gelmi A., Benussi L., Boghrati B., Navarro D. A. P., Mirabito L., Radi A., Kumari P., Najafabadi M. M., Pugliese G., Da Silva De Araujo F. T., Meola S., Amoozegar V., Lomidze D., Cabrera A., Dimitrov A., Bianco S., Goh J., Braghieri A., Aleksandrov A., Shopova M., Gupta R., Petkov P., Da Costa E. M., Sanchez-Hernandez A., Litov L., Hadjiiska R., Leszki S., De Lellis G., Asghar I., Pavlov B., Franco M., Montagna P., Eysermans J., Iaydjiev P., Rodozov M., Ebraimi M., Vazquez E., Bagaturia I., Bhatnagar V., Sarkar A., Santoro A., Lacalamita N., Crotty I., Margjeka I., El Sawy M., Grenier G., Lee K. S., Soultanov G., Marujo F., Muhammad S., Estrada C. U., Pedraza I., Loddo F., Herrera C. A. M., Ahmad A., Bernal C., Abbrescia M., Choi S. Y., Castilla-Valdez H., Colafranceschi S., Francois B., Bonchev M., Pierluigi D., Alves G. A., Vitulo P., Lee H., Aly R., Carrillo S., Ghasemi R., Russo A.   +110 more
core   +2 more sources

Bond Behavior Between Steel Bar and Reactive Powder Concrete Under Repeated Loading

Buildings
To investigate the influence of repeated loading on the bond behavior between steel bars and reactive powder concrete (RPC), this study conducted repeated loading tests on eight beam specimens and one static loading test as a control.
Dewen Zhang, Yanming Feng, Ruihui Han, Xiangsheng Kong, Dehong Wang, Chao Ren   +5 more
doaj   +1 more source

High-resolution timing of MIPs with RPCs – a model [PDF]

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2000
Abstract Resistive Plate Chambers made with glass and metal electrodes forming accurately spaced gas gaps of a few hundred micrometers have reached timing accuracies below 50 ps σ with efficiencies above 95%. This type of detector, operating at atmospheric pressure with non-flammable gases, seems well suited for large-area TOF systems, providing ...
openaire   +1 more source

Mechanism Analysis of the Influence of Delay Period on Mechanical Properties of Reactive Powder Concrete

Frontiers in Materials, 2021
In order to analyze the influence mechanism of delay period on the mechanical properties of reactive powder concrete (RPC), the compressive strength of RPC with delay periods of 18, 24, and 30 h was tested at the age of 7, 28, and 90 days, respectively ...
Xiaohui Wang, Xiaohui Wang, Qingxin Zhao, Xiaojun He, Shuang Zhang   +4 more
doaj   +1 more source

A novel harmonic resonance prevention measure for railway power conditioner–network–train interaction system

Railway Engineering Science
The integration of a large number of power electronic converters, such as railway power conditioner (RPC), introduces a series of problems, including harmonic interaction, stability issues, and wideband resonance, into the railway power supply system. To
Shaofeng Xie, Fan Zhong
doaj   +1 more source

Evolutionary radiation of large‐bodied gorgonopsians from the lower Abrahamskraal formation of South Africa

The Anatomical Record, EarlyView.
Abstract The middle Permian represents a critical interval in therapsid evolution, when gorgonopsians emerged as some of the first specialized apex predators within terrestrial ecosystems. Despite their significance, the early diversification of Gorgonopsia in Gondwana remains poorly understood due to scarcity and fragmentary material.
Zanildo Macungo, Ricardo Araújo, Bruce S. Rubidge, Michael O. Day, Kathleen N. Dollman, Julien Benoit   +5 more
wiley   +1 more source

A P-I Diagram Approach for Predicting Dynamic Response and Damage Assessment of Reactive Power Concrete Columns Subjected to Blast Loading

Buildings, 2022
Reactive power concrete (RPC) possesses high compressive strength, toughness, and durability, and it is increasingly being used in important buildings.
Qin Rong, Zhonghui Zhao, Xiaomeng Hou, Zhizhong Jiang   +3 more
doaj   +1 more source

High Temperature Behaviour of Reactive Powder Concrete (RPC) [PDF]

, 2014
This thesis looks into the behaviour of reactive powder concrete (RPC) when subjected to high temperature. It is divided into two parts. The first part reports the experimental programme involving testing of RPC mixes containing hybrid steel-PVA fibres ...
Sriskandarajah, Sanchayan
core   +1 more source

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source