Results 81 to 90 of about 7,638 (169)

Mutational screening of LCA genes emphasizing RPE65 in South Indian cohort of patients.

PLoS ONE, 2013
BackgroundLeber congenital amaurosis (LCA) is the most severe form of inherited retinal visual impairment in children. So far, mutations in more than 20 genes have been known to cause LCA and among them, RPE65 is a suitable candidate for gene therapy ...
Anshuman Verma, Vijayalakshmi Perumalsamy, Shashikant Shetty, Maigi Kulm, Periasamy Sundaresan   +4 more
doaj   +1 more source

Therapeutic potential of allogeneic iPS cell-derived RPE transplantation for RPE65-LCA

American Journal of Ophthalmology Case Reports
Purpose: To evaluate the safety and therapeutic effects of induced pluripotent stem (iPS) cell-derived retinal pigment epithelium (RPE) transplantation for RPE65-associated Leber congenital amaurosis (RPE65-LCA).
Akiko Maeda, Daiki Sakai, Satoshi Yokota, Midori Yamamoto, Sunao Sugita, Yasuhiko Hirami, Michiko Mandai, Tadao Maeda, Masayo Takahashi, Yasuo Kurimoto   +9 more
doaj   +1 more source

MALDI-TOF Lamprey RPE65 peptide mass fingerprinting.

, 2012
Theoretical monoisotopic masses for Lamprey RPE65 trypsin-generated peptides were determined by MS-Digest.
Susan Gentleman (116510), Maria Mercedes Campos (116507), Alexander N. Gubin (116502), Eugenia Poliakov (116500), Yan Li (23143), T. Michael Redmond (116515), Olivia Stearn (116504), Igor B. Rogozin (10987)   +7 more
core   +1 more source

Effect of Pulsed Low-Level Lasers on Adult versus Neonatal Human Retinal Pigment Epithelial Cells: An in-vitro Study

Journal of Ophthalmic & Vision Research
Purpose: To investigate the short-term effects of low-level lasers (LLLs; also known as low-power laser therapy) on the structure, genetic, and phenotype of cultured human retinal pigment epithelial (hRPE) cells from both adult and neonatal sources ...
Seyed Mohamadmehdi Moshtaghion, Mohammad Abolhosseini, Faraj Tabeie, Sahar Balagholi, Fatemeh Suri, Samira Karami, Houra Naraghi, Mozhgan Rezaei Kanavi, Somayeh Asadi   +8 more
doaj   +1 more source

S- and M/L-Cone Opsin Labelling Increased after LV-RPE65 Treatment of Rpe65^−/− Mice at P5

, 2013
(A) Double immunostaining of wild-type retina with antibodies directed against S-opsin (red) and M/L-opsin (green) localized in the outer segment. Note that some cones express both opsins while others are mainly labelled for only one of these opsins.
Alexis-Pierre Bemelmans (66149), Sylvain V Crippa (66151), Francis L Munier (66154), Andreas Wenzel (66155), Janis Lem (66153), Mathias W Seeliger (32419), Corinne Kostic (66150), William W Hauswirth (66152), Yvan Arsenijevic (49871)   +8 more
core   +1 more source

Histological Study on the Therapeutic Effect of Gene Modified Bone Marrow Hemopoeitic Stem Cells (BMHSCs) Versus Unmodified BMHSCs Derived Exosomes in Early Diabetic Retinopathy Male Rat Model

The Egyptian Journal of Histology
Background and Objectives: Globally, one of the main causes of blindness and vision impairment in the working class is diabetic retinopathy (DR). The goal of the current study was to evaluate and investigate the therapeutic benefits of bone marrow ...
Maha Zickri, Zeinab Hegab, Hala Metwally, Nour Abdelwahab, Hossam El Din Kareem, Mohammed Hameed, layth AbdulAdeem, Taha Yousif, Mohamed AbdelRahman, Amal Farag   +9 more
doaj   +1 more source

A novel mutation in the RPE65 gene causing Leber congenital amaurosis and its transcriptional expression in vitro.

PLoS ONE, 2014
The retinal pigment epithelium-specific 65 kDa protein is an isomerase encoded by the RPE65 gene (MIM 180069) that is responsible for an essential enzymatic step required for the function of the visual cycle.
Guoyan Mo, Qin Ding, Zhongshan Chen, Yunbo Li, Ming Yan, Lijing Bu, Yanping Song, Guohua Yin   +7 more
doaj   +1 more source

ERK1/2 pathway is activated in degenerated Rpe65-deficient mice

, 2013
The MAPK family is composed of three majors kinases, JNK, p38 and ERK1/2, and is implicated in many degenerative processes, including retinal cell death.
Emery, M., Cottet, S., Schorderet, D. F., Metrailler, S., Roduit, R., Schorderet, D.F.   +5 more
core   +1 more source

Rpe65-Gene Transfer Using an Integration-Deficient Lentiviral Vector

, 2010
Purpose: We previously demonstrated efficient retinal rescue of RPE65 mouse models (Rpe65-/- (Bemelmans et al, 2006) and Rpe65R91W/R91W mice) using a HIV1-derived lentiviral vector encoding for the mouse RPE65 cDNA.
Kostic, C., Arsenijevic, Y., Wanner, D., Philippe, S., Sarkis, C., Crippa, S., Pignat, V., Samardzija, M., Grimm, C., Mallet, J.   +9 more
core   +1 more source

iTRAQ-Based Proteomic Analysis of Visual Cycle-Associated Proteins in RPE of rd12 Mice before and after RPE65 Gene Delivery

Journal of Ophthalmology, 2015
Purpose. To investigate the iTRAQ-based proteomic changes of visual cycle-associated proteins in RPE of rd12 mice before and after RPE65 gene delivery. Mehtods.
Qinxiang Zheng, Yueping Ren, Radouil Tzekov, Shanshan Hua, Minghan Li, Jijing Pang, Jia Qu, Wensheng Li   +7 more
doaj   +1 more source