Results 111 to 120 of about 11,484 (198)

Regenerative Restoration Framework (RRF): A Global Initiative for Ecosystem Recovery and Community Empowerment

This project outlines the Regenerative Restoration Framework (RRF), an open-source, actionable plan designed to restore ecosystems, empower communities, and provide sustainable solutions to global environmental challenges.
ERI-IRFOS (Earth Refocus Institute - Interdisciplinary Research Facility for Open Sciences)
core   +2 more sources

Surviving Males With PORCN Variants: Expanding the Clinical, Molecular, and Mechanistic Spectrum

Clinical Genetics, Volume 110, Issue 5, Page 605-615, November 2026.
Pathogenic PORCN variants are compatible with male survival in both mosaic and non‐mosaic states, expanding the FDH/PONGOS spectrum and improving diagnosis and genetic counseling. ABSTRACT Pathogenic variants in PORCN cause focal dermal hypoplasia (FDH/Goltz syndrome), an X‐linked dominant disorder historically considered lethal in males, with milder ...
Lucía Miranda‐Alcaraz, Simone Carbonera, Mónica Mora‐Gómez, Natalia Gallego‐Zazo, Inmaculada Guillén, Elena Padilla, Gaia Visani, Alessia Asaro, Valeria Vásquez‐Amell, Mario Cazalla, Manuel Rodríguez‐Canó, Cristina Silván, Pedro Arias, Juan Andrés Jiménez‐Estrada, Tomás Valle, Alejandro Cruz‐Utrilla, Pilar Escribano‐Subías, Nuria Ochoa Parra, María Jesús del Cerro Marín, Julián Nevado, Spanish PAH Consortium, Pablo Lapunzina, Fabio Sirchia, Jair Tenorio‐Castano   +23 more
wiley   +1 more source

Intestinal elt-2 RNAi induces prominent phenotypes in rrf-1 mutants.

, 2012
The indicated C. elegans strains were raised on bacteria expressing elt-2 dsRNA and imaged by DIC microscopy on day 3 of adulthood. The rde-1 strain and the rde-1 strain expressing RDE-1 in the hypodermis (lin-26p::rde-1) were unaffected by RNAi, whereas
Malene Hansen (10367), Caroline Kumsta (166660)   +1 more
core   +1 more source

The Path-Breaking Potential of the Recovery and Resilience Facility: An Analysis of the Shifts in EU’s Distributional Policy Mode with Insights from Romania’s Experience [PDF]

Romanian Journal of European Affairs
In May 2020, the Recovery and Resilience Facility (RRF) was presented as a unique instrument, due to its ambition, form, and the mechanisms with which it is equipped.
Nicolae Toderaș
doaj  

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, Volume 78, Issue 10, Page 1324-1332, October 2026.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

A Cryopreservation‐Based Supply Chain Strategy for Extrusion Bioprinting in Space

Advanced Materials Technologies, Volume 11, Issue 20, 21 October 2026.
Extrusion bioprinting on crewed space platforms requires a bioink that stays functional along the logistic chain. Here, cells and biomaterial ink travel separately, the cells cryopreserved and the ink cold stored, and are combined only minutes before printing.
Johannes Windisch, Max von Witzleben, Richard Frank Richter, Finn Dani, Constantin Greil, Sarah Duin, Anja Lode, Michael Gelinsky   +7 more
wiley   +1 more source

rrf-1 mutants have increased sod-3 mRNA levels, a normal lifespan, and normal thermo-tolerance.

, 2012
(A) The sod-3 mRNA levels of a mixed population of C. elegans wild-type (WT, N2(A)) and rrf-1(pk1417).4x (rrf-1(pk1417) mutant outcrossed four times to WT(A)) strains were determined.
Malene Hansen (10367), Caroline Kumsta (166660)   +1 more
core   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, Volume 13, Issue 57, 14 October 2026.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

rrf-1 mutants are resistant to RNAi against the hypodermal gene bli-3, but are able to process gfp RNAi in seam cells.

, 2012
The indicated C. elegans strains were raised on bacteria expressing bli-3 dsRNA (A) and gfp dsRNA (B) and imaged by bright-field or fluorescence microscopy, respectively, on day 1 of adulthood.
Malene Hansen (10367), Caroline Kumsta (166660)   +1 more
core   +1 more source

Association of Clonal Hematopoiesis With Incident, Late‐Onset, Seropositive Rheumatoid Arthritis

Arthritis &Rheumatology, Volume 78, Issue 10, Page 2063-2073, October 2026.
Objective Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, CH of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA) and whether ...
Kun Zhao, Yash Pershad, J. Brett Heimlich, Michelle Ormseth, C. Michael Stein, Brian Sharber, Caitlyn Vlasschaert, Alexander G. Bick, Robert W. Corty   +8 more
wiley   +1 more source