Results 271 to 280 of about 696,870 (312)

Pimobendan alleviates myocyte apoptosis and fibrosis associated with mitral regurgitation by targeting endoplasmic reticulum stress

Animal Models and Experimental Medicine, EarlyView.
Mitral regurgitation (MR) causes volume overload and disrupts Ca2+ homeostasis. The volume overload leads to cardiac hypertrophy and fibrosis inferred from histopathological studies. Cardiac hypertrophy was identified by increased myocyte cross‐sectional area, left atrial‐to‐aortic root ratio, and left ventricular internal diameter at end‐diastole ...
Pakit Boonpala, Sushawadee Tongta, Nakkawee Saengklub, Vudhiporn Limprasutr, Sirinapa Srikam, Wilawan Ji‐au, Tussapon Boonyarattanasoonthorn, Yaowalak Panyasing, Sarawut Kumphune, Sarinee Kalandakanond‐Thongsong, Anusak Kijtawornrat   +10 more
wiley   +1 more source

Infections and genetic diversity of Cryptosporidium spp. and Giardia spp. in small wild mammals on the Eastern Tibetan plateau: public health implications. [PDF]

BMC Microbiol
Zuo Q, Bianba Z, Xue C, Liu H, Peng X, Zhou H, Zhang X, Chen Q, Li M, Yang Y, Zhou Y, Cao J, Yin J, Wang X, Shen Y.   +14 more
europepmc   +1 more source

Ein neuer Malariawirkstoff hemmt die Proteinsynthese von Plasmodium falciparum

Angewandte Chemie, EarlyView.
Die Verbindung 31 stellt einen vielversprechenden Ansatz für die Entwicklung eines Malariawirkstoffs mit einem starken Wirkungsprofil dar (PfNF54 IC50 ± s.d. = 3,9 ± 0,4 nM). Sie hat einen neuartigen Wirkmechanismus, indem sie an zytosolische Ribosomen‐Untereinheiten bindet und dadurch die Proteinsynthese im Parasiten hemmt.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

The emerging role of microbiota in lung cancer: a new perspective on lung cancer development and treatment. [PDF]

Cell Oncol (Dordr)
Yan C, Chen Y, Tian Y, Hu S, Wang H, Zhang X, Chu Q, Huang S, Sun W.   +8 more
europepmc   +1 more source

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum

Angewandte Chemie International Edition, EarlyView.
Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

Description of a New Telonemia Genus and Species With Novel Observations Providing Insights Into Its Hidden Diversity. [PDF]

J Eukaryot Microbiol
Mostazo-Zapata H, Gàlvez-Morante A, Berney C, Maya-Figuerola X, Sigona C, López-Escardó D, Sà EL, Vaqué D, Richter DJ.   +8 more
europepmc   +1 more source

Antibiotic Sensitivity of Vibrio spp. and Shewanella algae Isolated From Brood and Egg of Mud Crab Hatchery

Animal Research and One Health, EarlyView.
Vibrio alginolyticus NBRC 15630, Vibrio parahaemolyticus ATCC 17802, Shewanella algae DW01, and Shewanella algae ATCC 51192 bacterial strains were found in the Mud crab brood and egg samples. All isolates were found to be sensitive to cefotaxime, chloramphenicol, gentamicin, and nitrofurantoin antibiotics.
Abul Farah Md. Hasanuzzaman, Nurunnahar Nadira, Anup Sardar, Sabia Islam   +3 more
wiley   +1 more source

The alterations of airway and intestine microbiota in asthma: a systematic review and meta-analysis. [PDF]

Front Immunol
Li W, Lu K, Tang J, Chen Y, Lu Y, Hu X, Zhu H, Feng Y.   +7 more
europepmc   +1 more source

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source