Activation of Hypoxia Inducible Factor pathway for neuroprotection in in vitro models of ischaemic stroke [PDF]
, 2022 Ischaemic stroke is the most common form of stroke, accounting for appropriate 87% of all strokes. Reperfusion is the only immediate treatment option following ischaemic stroke, however, this option is only applicable to a small percentage of patients ...
Singh, Ayesha
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Polypharmacy in atrial fibrillation: An analysis of prospective outcomes using the Clinical Practice Research Datalink (CPRD) [PDF]
, 2022 Objectives: Observational studies of polypharmacy and the risk of death or ischaemic stroke in individuals with atrial fibrillation (AF) have produced inconsistent findings.
Scott, Natasha
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Patient's Understanding and Attititudes Towards Infliximab and Etanercept Biosimilars
, 2017 BackgroundInfliximab and etanercept biosimilars present significant potential cost savings to the NHS. Patients need to be involved in the decision to use these medicines but there is a limited published literature on their knowledge and attitudes about ...
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Effects of ageing on the vulnerability of the substantia nigra pars compacta dopaminergic neurons: implications in Parkinson’s disease [PDF]
, 2020 The degeneration of dopaminergic neurons (DAn) in the midbrain substantia nigra pars compacta (SNpc) is a definitive feature of Parkinson's disease (PD).
Gómez Gálvez, Yolanda
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, 2023 Cancer incidence rates are increasing world-wide including in the UK. An increase in cancer cases puts further pressure on pathology departments that are often already struggling to meet targets to diagnose cancers in a timely manner. Delays in diagnosis
Dowling, Lewis Michael Morgan
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Characterising the molecular consequences of LMNA mutations in congenital muscular dystrophy
, 2023 LMNA-related congenital muscular dystrophy (L-CMD) is a rare disorder predominantly causing muscle weakness and wasting, over time, leading to development of dysphagia and life-threating respiratory insufficiency, and sometimes cardiac arrhythmias. There
Storey, Emily Carolyn
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SUCCESSFUL ISOLATION AND CULTURE OF MULTIPOTENTIAL DISTAL AIRWAY STEM CELLS FROM COPD PATIENTS [PDF]
, 2022 Chronic Obstructive Pulmonary Disease (COPD) presents a significant, incurable, worldwide health burden, identifying it as a prospective regenerative medicine target.
Dale
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The co-administration of anticancer and pro-apoptotic agents as a novel approach in liver cancer therapy [PDF]
, 2018 Hepatocellular carcinoma accounts for 85% of primary liver cancer that are usually characterised by defective or ineffective apoptosis which is considered to be the main cause of cancer progression.
AL-Shakarchi, Wejdan
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Determining the role of epigenetics in telomerase regulation [PDF]
, 2022 Telomeres are guanine-rich 5'-TTAGGG-3' repeats found at the ends of human chromosomes that protect chromosomes from degradation and also provide stabilization.
Dogan, Fatma
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