Results 81 to 90 of about 37,268 (291)

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Responsabilidad social empresarial y gestión humana: una relación estratégica aplicada desde un modelo explicativo

Entramado, 2014
El presente trabajo tiene como objetivo explicar la relación entre la Responsabilidad Social Empresarial (RSE) y la Gestión Humana, aplicando un modelo explicativo en una empresa colombiana.
Juan David Peláez-León, Mónica García-Solarte   +1 more
doaj  

Multiscale Modeling of an 8‐Week Combination Regimen of Bemnifosbuvir and Ruzasvir in Patients with Chronic Hepatitis C Virus Infection

Clinical Pharmacology &Therapeutics, EarlyView.
Bemnifosbuvir (BEM) and ruzasvir (RZR) are pan‐genotypic HCV polymerase (NS5B) and NS5A inhibitors, respectively. In a single‐arm study (NCT05904470), 215 treatment‐naïve, adherent participants with chronic HCV (with or without cirrhosis) received BEM 550 mg QD plus RZR 180 mg QD for 8 weeks.
Carolin Zitzmann, Ruy M. Ribeiro, Aurelien Marc, Xiao‐Jian Zhou, Alan S. Perelson   +4 more
wiley   +1 more source

RSE Worldwide: Opportunities to Strengthen the Global RSE Community

By Michelle Barker, Sandra Gesing, Rowland Mosbergen, Uwe Schmitt, Carlos Martinez-Ortiz September 2024 The RSE Worldwide sessions at this year's Research Software Engineering Conference (RSECon) in the UK continue to address the importance of connecting these emerging communities with the global research software community. The RSE community continues
Michelle Barker, Sandra Gesing, Rowland Mosbergen, Uwe Schmitt, Carlos Martinez-Ortiz   +4 more
  +4 more sources

Development of interactive maps of geolocations of native plants of Kazakhstan and the living collections of the Mangyshlak experimental botanical garden [PDF]

BIO Web of Conferences
The purpose of this article is to identify problems, demonstrate results and assess the prospects for compiling interactive digital maps of native plants of Kazakhstan and the MEBG living collections, to be distributed through the Internet.
Imanbayeva Akzhunis, Belozerov Ivan, Musaeva Zhanna, Hasanova Gulnara   +3 more
doaj   +1 more source

Model‐Informed Approaches for Pediatric Type 2 Diabetes Evidence Generation: Insights from a Model‐Based Longitudinal HbA1c Meta‐Analysis from EMA Marketing Authorization Applications

Clinical Pharmacology &Therapeutics, EarlyView.
Evidence generation for antihyperglycemic therapies in pediatric type 2 diabetes mellitus (T2DM) remains challenging, with most randomized trials failing to demonstrate statistically significant reductions in glycated hemoglobin (HbA1c), partly due to substantial between‐subject variability.
Pieter J. Colin, Efthymios Manolis, Jeroen V. Koomen   +2 more
wiley   +1 more source

ASSESSING UNEMPLOYMENT RATES IN TANAH DATAR REGENCY: INSIGHTS FROM SMALL AREA ESTIMATION

Barekeng
Unemployment is a significant issue in Indonesia's labor market. The unemployment rate is measured by the Open Unemployment Rate (OUR) through the National Labor Force Survey (SAKERNAS) conducted by BPS.
Rara Sandhy Winanda, Yasyfin Ikrima Khairani, Fajar Wisga Permana   +2 more
doaj   +1 more source

sj-docx-3-rse-10.1177_07419325231176762 – Supplemental material for Executive Function, Perceived Stress, and Academic Performance Among Middle Schoolers With and Without Behavior Problems

, 2023
Supplemental material, sj-docx-3-rse-10.1177_07419325231176762 for Executive Function, Perceived Stress, and Academic Performance Among Middle Schoolers With and Without Behavior Problems by Michelle M. Cumming, Rachel Oblath, Yuxi Qiu, Stacy L. Frazier,
Rachel Oblath (10320265), Jeehyun Park (5559371), Helen Flores (16379787), Michelle M. Cumming (7385414), Philip David Zelazo (4886926), Stacy L. Frazier (16379784), Yuxi Qiu (11321715)   +6 more
core   +1 more source

Exposure‐Response Analyses of Datopotamab Deruxtecan (Dato‐DXd), a TROP2‐Directed Antibody‐Drug Conjugate, in Advanced Non‐small Cell Lung Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure‐response analyses supported a favorable benefit‐risk profile of Dato‐DXd at 6 mg/kg Q3W in patients with advanced nonsquamous NSCLC. Datopotamab deruxtecan (Dato‐DXd) is a trophoblast cell‐surface antigen‐2 (TROP2)‐directed antibody‐drug conjugate (ADC) that has demonstrated clinical activity in patients with NSCLC who have received prior ...
Ying Hong, Anna M. Mc Laughlin, Yuzhuo Pan, Sofia Friberg Hietala, Sophie Peigné, Michael Chargualaf, Zoey Tang, Diansong Zhou, Naoyuki Tajima, Malaz Abutarif, Tushar Garimella   +10 more
wiley   +1 more source

Les dessous d’un business model : Cas Oriflame Tunisie

Revue Marocaine de Recherche en Management et Marketing, 2016
L’objectif de notre communication est de comprendre la construction du Business Model ou modèle d’affaires d’un nouvel entrant dans le secteur de la vente directe des produits cosmétiques en Tunisie.
SAMEH BEN AMMAR, SONIA MBARKI
doaj