Results 141 to 150 of about 173,960 (378)

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz   +15 more
wiley   +1 more source

Mapping and Innovating Business Models of Food Hubs in Short Food Supply Chains

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Short food supply chains (SFSCs) offer sustainable alternatives to conventional food systems (CFSCs) but require effective intermediaries to scale and remain competitive. Food Hubs (FHs) serve this role by enhancing SFSC efficiency and market reach while upholding community‐oriented values. However, limited research has examined how FHs design
Marije Renkema‐Singh   +2 more
wiley   +1 more source

Paediatric developmental safety and the ICH E11A extrapolation of safety

open access: yes
British Journal of Clinical Pharmacology, EarlyView.
Gilbert J. Burckart   +6 more
wiley   +1 more source

Predictive value of seizure onset for gross motor dysfunction in individuals with pathogenic GABRB2 and GABRB3 variants

open access: yesEpilepsia, EarlyView.
Abstract Objective Pathogenic variants in γ‐aminobutyric acid type A (GABAA) receptor genes have been associated with a wide spectrum of neurological disorders. We aimed to delineate the clinical trajectories associated with gain‐of‐function (GoF) and loss‐of‐function (LoF) variants in GABRB2 and GABRB3, and to develop a risk‐prediction model for gross
Sebastian Ortiz   +73 more
wiley   +1 more source

Sustainable Optimization of Emissions and Performance in Hydrogen Port Injection Diesel Engines Through Port Timing and Injection Duration Modulation

open access: yesEnergy Science &Engineering, EarlyView.
Optimizing hydrogen port injection in diesel engines significantly improves efficiency and reduces emissions, demonstrating a sustainable dual‐fuel strategy for cleaner transportation solutions and lower environmental impact. ABSTRACT This study evaluates a single‐cylinder hydrogen port injection (HPFI) Diesel engine by systematically varying the ...
Kaustubh R. Kapadani   +7 more
wiley   +1 more source

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