Results 51 to 60 of about 917 (167)

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

Pectinase‐Based Bioprocesses for Circular Bioeconomy and Sustainable Industrial Development

Biotechnology and Bioengineering, EarlyView.
This picture demonstrates a unified strategy for sustainable pectinase production, focusing on microbial bioproduction, innovative strategies in enzyme engineering (Protein engineering, rational enzyme design, directed evolution and heterologous expression) and various applications in industry, including food, textiles, pulp and paper, agriculture and ...
Nisha Sharma, Dimple Tanwar, Usha Grewal, Murugesan Mohana Keerthi, Yogesh K. Ahlawat, Nitin Pandey, Chirag G. Makvana   +6 more
wiley   +1 more source

Precision Synthesis of Biomass‐Derived Graphene‐Like Carbon With Tailored Crystallinity via Controlled Flash Joule Heating

Carbon Energy, EarlyView.
A dual‐phase flash Joule heating strategy converts pre‐pyrolyzed biomass into structurally tunable carbon materials from waste feedstocks. By decoupling current‐driven thermodynamic input and duration‐dependent kinetic relaxation, the process maps the transition from amorphous carbon to few‐layer turbostratic graphene and turbostratic nanographite ...
Jiawen Zeng, Yichen Dong, Niyuan Zhu, Danchen Zhu, Hao Jiang, Yingquan Chen, Tong Han, Yonggang Yao, Hanping Chen, Haiping Yang   +9 more
wiley   +1 more source

Experimental Investigation on the Effect of Dry and Wet Activation Processes on the Morphological Properties of Activated Carbon Derived From Sugarcane Bagasse

Carbon Innovation, EarlyView.
Synthesis and characterization of sugarcane bagasse‐derived activated carbon via KOH‐assisted dry and wet activation. ABSTRACT This study explores the impact of activation processes on the morphological properties of activated carbon. Carbon is initially produced through vacuum pyrolysis at three temperatures (500°C, 600°C, and 700°C), with a heating ...
Sachin Channappa Hallad, N. L. Panwar, Kavankumar Venkatareddy, J. K. Maherchandani, Trilok Gupta, S. S. Meena   +5 more
wiley   +1 more source

Antisolvent crystallization of lithium hydroxide monohydrate: Significant factors and kinetics analysis

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract Crystallization is the final stage in lithium hydroxide monohydrate (LiOH · H2O) production, and antisolvent crystallization offers a lower‐energy route compared with evaporative methods. In this study, we investigated bench‐scale ethanol‐based antisolvent crystallization of LiOH · H2O, and identified the significant impact parameter via a ...
Chentao He, Liuyin Xia
wiley   +1 more source

Box–Behnken optimization and ANN‐ANFIS integrated modelling for transesterification using thermally activated basic oxygen furnace slag catalyst

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract Global energy demand and environmental concerns have intensified the search for renewable and sustainable energy sources. This study thus, focuses on optimizing the transesterification process of waste cooking oil (WCO) using thermally activated basic oxygen furnace slag catalyst calcined at 850°C (BOF 850). The optimization and modelling were
Johra S. Ali, Hillary L. Rutto
wiley   +1 more source

Review of CFD modelling techniques for single‐phase and multiphase flow in static mixers

The Canadian Journal of Chemical Engineering, EarlyView.
This review synthesizes computational fluid dynamics (CFD) approaches for static mixers, linking hydrodynamics to pressure drop, particle/droplet distributions, mixing metrics, and heat‐transfer performance to guide modelling choices and design decisions. Abstract Static mixers enable compact and low‐energy intensification.
Jussan Jaeger, Sálvio Lima de Carvalho Neto, Silvio Edegar Weschenfelder, Glaucia Rodrigues Vieira de Almeida da Fonseca, Maria de Fátima Rodrigues da Cunha, Selene Maria Arruda Guelli Ulson de Souza, Evandro Balestrin, Adriano da Silva   +7 more
wiley   +1 more source

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

A prospective natural history study protocol for clinical trial readiness in synaptic disorders

Epilepsia, EarlyView.
Abstract Objective STXBP1‐related disorder (STXBP1‐RD) and SYNGAP1‐related disorder (SYNGAP1‐RD) are two common genetic synaptopathies that are associated with epilepsy, developmental delay, intellectual developmental disorder, and behavioral problems.
Jillian L. McKee, Sarah M. Ruggiero, Kristin Cunningham, JoeyLynn Coyne, Ian McSalley, Michael C. Kaufman, Bintou Bane, Torrey Chisari, Jonathan Toib, Carlyn Glatts, Sarah Tefft, Julie M. Orlando, Viveknarayanan Padmanabhan, Alexander K. Gonzalez, Alicia Harrison, Charlene Woo, Stephanie A. Zbikowski, Rency Dhaduk, Johanna Mercurio, Macie McCarthy, Jan H. Magielski, Zachary Grinspan, Megan Abbott, Juliet Knowles, Hsiao‐Tuan Chao, Katherine Xiong, Elizabeth Berry‐Kravis, Sepideh Tabarestani, J. Michael Graglia, Kathryn Helde, Virginie McNamar, Charlene Son Rigby, James Goss, Scott Demarest, Andrea Miele, Benjamin Prosser, Michael J. Boland, Samuel R. Pierce, Ingo Helbig   +38 more
wiley   +1 more source

Paediatric developmental safety and the ICH E11A extrapolation of safety

British Journal of Clinical Pharmacology, EarlyView.
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Rebecca Racz, Sherbet Samuels, Dionna J. Green, Lynne P. Yao   +6 more
wiley   +1 more source