Results 141 to 150 of about 77,778 (298)

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2349-2363, July 2026.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

Enhancing Volatility Prediction: A Wavelet‐Based Hierarchical Forecast Reconciliation Approach

Journal of Forecasting, Volume 45, Issue 4, Page 1652-1664, July 2026.
ABSTRACT Forecasting realized volatility (RV) has been widely studied, with numerous techniques developed to enhance predictive accuracy. Among these techniques, the use of RV decompositions based on intraday asset returns has been applied. However, the use of a frequency‐based decomposition, which provides unique insights into the dynamics of RV ...
Adam Clements, Ajith Perera
wiley   +1 more source

Serum and mucosal antibody-mediated protection and identification of asymptomatic respiratory syncytial virus infection in community-dwelling older adults in Europe

Frontiers in Immunology
IntroductionRespiratory syncytial virus (RSV) causes acute respiratory tract infection (ARTI) and reinfects adults throughout life, posing a risk for hospitalization in older adults (>60 years) with frailty and comorbidities.MethodsTo investigate ...
Deniz Öner, Charlotte Vernhes, Sunita Balla-Jhagjhoorsingh, Annick Moureau, Marjolein Crabbe, Bruno Salaun, Arangassery Rosemary Bastian, Kim Thys, Jonathan De Smedt, Salo N. Ooft, Koos Korsten, Koos Korsten, Niels Adriaenssens, Niels Adriaenssens, Samuel Coenen, Samuel Coenen, Christopher C. Butler, Theo J. M. Verheij, Simon B. Drysdale, Simon B. Drysdale, Joanne G. Wildenbeest, Andrew J. Pollard, Peter J. M. Openshaw, Louis Bont, Jeroen Aerssens   +24 more
doaj   +1 more source

Respiratory syncytial virus infection among children younger than 2 years admitted to a paediatric intensive care unit with extended severe acute respiratory infection in ten Gavi-eligible countries: the RSV GOLD—ICU Network study [PDF]

Background: Patient-level data on life-threatening respiratory syncytial virus (RSV) infection in children in low-income and lower-middle-income countries (LMICs) are scarce, and this scarcity might limit demand for RSV interventions in LMICs who rely on
RSV GOLD—ICU Network collaborators
core  

Resveratrol Attenuates Obesity by Inducing GDF15 Expression via the p38‐ATF3 Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Resveratrol dose‐dependently upregulates GDF15 expression in murine and human cells via the p38‐ATF3 signaling axis. In high‐fat diet fed mice, resveratrol elevates systemic and tissue GDF15 levels, thereby reducing food intake and weight gain and conferring resistance to diet‐induced obesity. This study identifies a novel p38‐ATF3‐GDF15 axis mediating
Liufeng Mao, Yunliang Hou, Weifang Liu, Jianbin Chen, Wanli Hu, Wengong Jiang, Tao Nie   +6 more
wiley   +1 more source

Best Practices for Identifying Hospitalized Lower Respiratory Tract Infections Using Administrative Data: A Systematic Literature Review of Validation Studies

Infectious Diseases and Therapy
Introduction Estimating the burden of lower respiratory tract infections (LRTIs) increasingly relies on administrative databases using International Classification of Diseases (ICD) codes, but no standard methodology exists. We defined best practices for
Germaine Hanquet, Christian Theilacker, Jeffrey Vietri, Ingrid Sepúlveda-Pachón, Sonia Menon, Bradford Gessner, Elizabeth Begier   +6 more
doaj   +1 more source

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen, Yupan Bai, Lu Shen, Jiacheng Ying, Jie Xu, Jiayin Tang, Yujie Bao   +6 more
wiley   +1 more source

RNA interference in crop protection: opportunities and challenges during the transition to commercialization

Pest Management Science, Volume 82, Issue 7, Page 5971-5986, July 2026.
RNA interference (RNAi) technologies, host‐induced gene silencing (HIGS) and spray‐induced gene silencing (SIGS), potentially offer sustainable crop protection. However, efficacy, costs, regulatory clarity, and socio‐environmental impacts require further evaluation for broader use.
Elisabetta Sergi, Anna Narduzzo, Alessandra Di Canito, Francesco Favaretto, Luca Nerva, Walter Chitarra, Lucia Bologna, Jacopo Bacenetti, Giuliana Maddalena, Simona Masiero, Ileana Vigentini, Gabriella De Lorenzis, Silvia Laura Toffolatti   +12 more
wiley   +1 more source

Five Years’ Experience with Respiratory Syncytial Virus Among Hospitalized Patients: A Retrospective Study from Jazan, Saudi Arabia

Infection and Drug Resistance
Nabil S Dhayhi,1,* Ali Aqeel,2,* Salman Ghazwani,3 Ibrahim M Gosadi,4 Haleemah Mohammed AlQassimi,5 Abdullah Thubab,6 Ibrahim Abdullah Sairam,6 Majed Ahmed Hakami,6 Fahd Ahmed Sawan,6 Sabreen Mohammed Asiry,7 Mawahib Khalifa,7 Hadi Daghreeri,8 ...
Dhayhi NS, Aqeel A, Ghazwani S, Gosadi IM, AlQassimi HM, Thubab A, Sairam IA, Hakami MA, Sawan FA, Asiry SM, Khalifa M, Daghreeri H, Badawy A, Ghawi AA, Arishi H, Almudeer A, Shrwani KJ, Alhazmi AH   +17 more
doaj  

Immune correlates analysis of mRNA-1345 RSV vaccine efficacy clinical trial

Nature Communications
Identifying an immunologic marker as a correlate of protection (CoP) for RSV vaccination is important. In the pivotal phase 3 trial, the mRNA-1345 vaccine demonstrated efficacy against RSV in older adults (NCT05127434).
Chong Ma, Jiejun Du, Lan Lan, Archana Kapoor, Gonzalo Perez Marc, Gilberto Jimenez, Christopher J. A. Duncan, Nancy Le Cam, Nina Lin, Frances Priddy, Sanjay Garg, Sonia K. Stoszek, Christine A. Shaw, Jaya Goswami, Eleanor Wilson, Rituparna Das, Honghong Zhou, Lingyi Zheng   +17 more
doaj   +1 more source