Results 291 to 300 of about 2,171,089 (338)

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

Endometrial factors and pregnancy loss frequency in recurrent pregnancy loss patients: comparing RT-PCR microbiology, microbial cultures, and immunohistochemistry of endometrium biopsy. [PDF]

J Appl Genet
Klimaszyk K, Wirstlein P, Bednarek-Rajewska K, Jankowski M, Svarre Nielsen H, Wender Ożegowska E, Kędzia M.   +6 more
europepmc   +1 more source

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, EarlyView.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source

Selection of optimal extraction and RT-PCR protocols for stool RNA detection of colorectal cancer associated immune genes. [PDF]

Sci Rep
Omran TA, Madsø IL, Sæther PC, Bemanian V, Tunsjø HS.   +4 more
europepmc   +1 more source

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source

Assessing RNA integrity by digital RT-PCR: Influence of extraction, storage, and matrices. [PDF]

Biol Methods Protoc
Wurtzer S, Duvivier M, Accrombessi H, Levert M, Richard E, Moulin L.   +5 more
europepmc   +1 more source

Evaluation of Fecal Sample Pooling for Real-Time RT-PCR Testing SARS-CoV-2 in Animals. [PDF]

Viruses
Leonardi-Cattolica A, Kayastha S, Miller M, Guag J, Tkachenko A, Lowe J, Allender M, Terio K, Wang L.   +8 more
europepmc   +1 more source

Broad-spectrum dengue virus detection using the commercial RealStar dengue RT-PCR kit 3.0 (Altona) and an in-house combined real-time RT-PCR assay. [PDF]

Heliyon
Luciani L, Combe P, Touret F, Gazin C, Klitting R, Pezzi L, Thirion L, Charrel R, Grard G, de Lamballerie X, Nougairède A.   +10 more
europepmc   +1 more source

Comparison of Bordetella species identification among differing rt-PCR assays in the United States. [PDF]

Microbiol Spectr
Cole M, Simon AK, Faulkner A, Skoff T, Tondella ML, Montero C, Nye MB, Williams M.   +7 more
europepmc   +1 more source