Results 291 to 300 of about 2,220,062 (335)

Cancer Immunotherapy via Disruption of Integrin αvβ3 and CD47 Costabilization on Cancer Cell Surface

open access: yesAdvanced Science, EarlyView.
This study identifies a cancer‐specific interaction between CD47 and integrin αvβ3 that facilitates immune evasion. A rationally designed peptide, PSFL‐NK13, disrupts this axis, enhancing macrophage‐mediated phagocytosis and suppressing tumor growth without inducing anemia.
Peng‐Cheng Yu   +12 more
wiley   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

open access: yesAdvanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang   +16 more
wiley   +1 more source

Laboratory-based molecular test alternatives to RT-PCR for the diagnosis of SARS-CoV-2 infection. [PDF]

open access: yesCochrane Database Syst Rev
Arevalo-Rodriguez I   +15 more
europepmc   +1 more source

SARS-CoV-2 Variants May Affect Saliva RT-PCR Assay Sensitivity. [PDF]

open access: yesJ Appl Lab Med
Chwa JS   +10 more
europepmc   +1 more source

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