Results 1 to 10 of about 99,956 (120)
Discovery and Characterization of Unusual O-Linked Glycosylation of IgG4 Antibody Using LC-MS. [PDF]
Rapid Commun Mass SpectromABSTRACT Background Consensus is that immunoglobulin IgG4 contains only N‐linked glycosylation. The analysis of several batches of commercial biopharmaceutical product Dupixent using top‐down intact mass spectrometry revealed that this IgG4 features a small amount of O‐linked glycosylation in the Fab region.
Janecki DJ, Kao-Scharf CY, Hoffmann A.
europepmc +2 more sources
Progress in experimental models to investigate the in vivo and in vitro antidiabetic activity of drugs. [PDF]
Animal Model Exp MedAbstract Diabetes mellitus is one of the world's most prevalent and complex metabolic disorders, and it is a rapidly growing global public health issue. It is characterized by hyperglycemia, a condition involving a high blood glucose level brought on by deficiencies in insulin secretion, decreased activity of insulin, or both.
Janapati YK, Junapudi S.
europepmc +2 more sources
Antigen presentation of post-translationally modified peptides in major histocompatibility complexes. [PDF]
Immunol Cell BiolT cells recognize pathogens and malignantly transformed cells through antigen presentation on major histocompatibility complex molecules. Post‐translational modifications (PTMs) of proteins can alter the peptides presented, influencing immune recognition and disease.
de Wit AS, Bianchi F, van den Bogaart G.
europepmc +2 more sources
Parental Conflict in the Context of Multiethnoracial Relationships [PDF]
, 2021 The percent of families with parents from different racial or ethnic backgrounds has risen exponentially in the last decades. Approximately 14% of children were born into multiethnoracial (MER) families in the United States in 2015, more than double the ...
Rowley, Christina A
core +2 more sources
Frontiers in Cardiovascular Medicine, 2022 BackgroundMyocardial ischemia/reperfusion (I/R) injury is the main obstacle to percutaneous coronary intervention, lacking effective therapeutic measures in a clinical setting.
Xiaohong Wei +9 more
doaj +1 more source
Frontiers in Genetics, 2021 Understanding heat stress physiology and identifying reliable biomarkers are paramount for developing effective management and mitigation strategies. However, little is known about the molecular mechanisms underlying thermal tolerance in animals.
Jinhuan Dou +6 more
doaj +1 more source
Using Applied Conversation Analysis in Patient Education
Global Qualitative Nursing Research, 2021 The conversation strategies patients and clinicians use are important in determining patient satisfaction and adherence, and health outcomes following patient education—yet most studies are rife with surveys and interviews which often fail to account for
Sean N. Halpin +2 more
doaj +1 more source
BMC Nursing, 2021 Background Bullying among nurses is a universally recognized problem that has important consequences for nurses, patients and health institutions. This research was conducted with the aim of studying the relationship between role conflict, negative ...
Atefeh Homayuni +3 more
doaj +1 more source
Rev Rene, 2021 Objective: to analyze the use of elements of effective nurse-patient communication in the light of the Transcultural Interprofessional Practice model. Methods: an integrative literature review was carried out in the CINAHL, LILACS, MEDLINE, SCOPUS, and ...
Josefa Fernanda Evangelista de Lacerda +5 more
doaj +1 more source
Community Dentistry and Oral Epidemiology, Volume 51, Issue 6, Page 1130-1140, December 2023., 2023 Abstract Background Realist methods offer a novel approach to intervention design. Such novelty is needed for effective oral health promotion interventions with people with intellectual developmental disabilities (IDD) and their carers because existing interventions are poorly described and lack theoretical underpinning.
Caoimhin Mac Giolla Phadraig +9 more
wiley +1 more source