Results 1 to 10 of about 849,964 (166)

Comprehensive RNA-Seq Profiling Reveals Temporal and Tissue-Specific Changes in Gene Expression in Sprague–Dawley Rats as Response to Heat Stress Challenges

open access: yesFrontiers in Genetics, 2021
Understanding heat stress physiology and identifying reliable biomarkers are paramount for developing effective management and mitigation strategies. However, little is known about the molecular mechanisms underlying thermal tolerance in animals.
Jinhuan Dou   +6 more
doaj   +2 more sources

Discovery and Characterization of Unusual O-Linked Glycosylation of IgG4 Antibody Using LC-MS. [PDF]

open access: yesRapid Commun Mass Spectrom
ABSTRACT Background Consensus is that immunoglobulin IgG4 contains only N‐linked glycosylation. The analysis of several batches of commercial biopharmaceutical product Dupixent using top‐down intact mass spectrometry revealed that this IgG4 features a small amount of O‐linked glycosylation in the Fab region.
Janecki DJ, Kao-Scharf CY, Hoffmann A.
europepmc   +2 more sources

Progress in experimental models to investigate the in vivo and in vitro antidiabetic activity of drugs. [PDF]

open access: yesAnimal Model Exp Med
Abstract Diabetes mellitus is one of the world's most prevalent and complex metabolic disorders, and it is a rapidly growing global public health issue. It is characterized by hyperglycemia, a condition involving a high blood glucose level brought on by deficiencies in insulin secretion, decreased activity of insulin, or both.
Janapati YK, Junapudi S.
europepmc   +2 more sources

Proteomics Revealed That Mitochondrial Function Contributed to the Protective Effect of Herba Siegesbeckiae Against Cardiac Ischemia/Reperfusion Injury

open access: yesFrontiers in Cardiovascular Medicine, 2022
BackgroundMyocardial ischemia/reperfusion (I/R) injury is the main obstacle to percutaneous coronary intervention, lacking effective therapeutic measures in a clinical setting.
Xiaohong Wei   +9 more
doaj   +1 more source

Optimalisasi Pendokumentasian Case Manager Rumah Sakit Tipe A Di Jakarta

open access: yesJurnal Kepemimpinan dan Manajemen Keperawatan, 2021
Case management di Indonesia dikenal dengan Manajemen Pelayanan Pasien (MnPP) dan case manager disebut dengan Manajer Pelayanan Pasien (MPP). Fungsi case manager yaitu melakukan asesmen, perencanaan hingga evaluasi, koordinasi, advokasi, edukasi, serta ...
Yandih Mardean   +3 more
doaj   +1 more source

Genetic Characteristics of the Even Breed of Deer in Yakutia

open access: yes, 2021
Microsatellite markers Rt6, BMS1788, Rt 30, Rt1, Rt9, FCB193, Rt7, BMS745, C 143, Rt24, OheQ, C217, C32, NVHRT16, T40, C276 were used to study the genetic profile of the Even breed of deer cultivated in Yakutia.
V. Dodokhov   +3 more
semanticscholar   +1 more source

Contextual barriers of respectful workplace in nursing: A focused ethnography

open access: yesIranian Journal of Nursing and Midwifery Research, 2021
Background: Respectful relationship among nurses is an important influencing factor of positive work environment and nursing outcomes. Disrespectful interpersonal behaviors set the scene for an unpleasant and unhealthy workplace in nursing.
Azadeh Nouri   +3 more
doaj   +1 more source

RESISTANCE TRANING PROTOCOLS PROMOTE STRENGTH INCREASE WITHOUT MORPHOLOGICAL CHANGES

open access: yesRevista Brasileira de Medicina do Esporte, 2020
Introduction Resistance training (RT) has been related to increased protein synthesis, and in the myocardium it triggers morphological adaptations that result in improved cardiac contractility. In skeletal muscle, RT promotes an improvement in functional
A. Damiani   +8 more
semanticscholar   +1 more source

RECOGNITION OF THE OTHER FOR THE EFFECTIVE WORK OF THE REHABILITATION NURSE: AXEL HONNETH REFERENCE

open access: yesRevista Portuguesa de Enfermagem de Reabilitação, 2020
Objective: to reflect on the potential of the Theory of Recognition for the professional practice of rehabilitation nurses. Method: reflective theoretical study based on the framework of Axel Honneth and the specific skills of rehabilitation nurses ...
Diana Raquel Meireles Pinto   +3 more
doaj   +1 more source

BENEFITS OF INTRADIALITIC PHYSICAL EXERCISE: SYSTEMATIC REVIEW

open access: yesRevista Portuguesa de Enfermagem de Reabilitação, 2020
Introduction: According to data from the Portuguese Society of Nephrology, in Portugal on December 31 of 2018, 12,227 patients underwent hemodialysis treatment (HD).
André Martins   +4 more
doaj   +1 more source

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