Results 91 to 100 of about 1,677,918 (224)

Distribuição geográfica dos óbitos de idosos por acidente de trânsito

Escola Anna Nery, 2016
Resumo Objetivo: Analisar os acidentes de trânsito envolvendo idosos em que ocorreu desfecho fatal, segundo condição do acidentado, local de ocorrência e causa do óbito, elaborando mapas de distribuição geográfica. Métodos: Estudo transversal realizado
Ana Maria Ribeiro dos Santos, Rosalina Aparecida Partezani Rodrigues, Claudia Benedita dos Santos, Gustavo Bussi Caminiti   +3 more
doaj   +1 more source

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers

ACS Medicinal Chemistry Letters, 2018
Somatic point mutations at a key arginine residue (R132) within the active site of the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) confer a novel gain of function in cancer cells, resulting in the production of d-2-hydroxyglutarate (2-HG), an ...
Janeta Popovici-Muller, R. Lemieux, Erin Artin, J. Saunders, F. Salituro, J. Travins, Giovanni Cianchetta, Z. Cai, Ding Zhou, D. Cui, Ping Chen, K. Straley, E. Tobin, F. Wang, M. David, V. Penard-Lacronique, C. Quivoron, V. Saada, S. de Botton, S. Gross, L. Dang, Hua Yang, L. Utley, Yue Chen, HyeRyun Kim, Shengfang Jin, Zhiwei Gu, Gui Yao, Zhiyong Luo, Xiaobing Lv, Cheng Fang, Liping Yan, A. Olaharski, L. Silverman, S. Biller, Shinsan M. Su, K. Yen   +36 more
semanticscholar   +1 more source

Mitochondrial Dysfunction in Neurodegenerative Diseases

MedComm, Volume 6, Issue 9, September 2025.
Overview of mitochondrial dysfunction in neurodegenerative diseases (NDDs). Mitochondrial dysfunction in NDDs involves impaired ATP synthesis, Ca2+ imbalance, oxidative stress, and apoptosis. Assessment methods integrate functional assays, omics, and imaging.
Chongyang Chen, Yujie Zhao, Jing Wang, Donghui Pan, Xinyu Wang, Yuping Xu, Junjie Yan, Lizhen Wang, Xifei Yang, Ming Lu, Gong‐Ping Liu   +10 more
wiley   +1 more source

Empirical assessment of the role of RT1-DOb as a switch gene for the {Csf1r, Milr1} gene pair in AD development.

, 2023
(A) Comparison of normalized expression levels of Csf1r and Milr1A at different expression levels of RT1-DOb; (B) Comparison of expression levels of the putative switch gene RT1-DOb gene in the hippocampus of AD model rats and control rats.
Sayed-Amir Marashi (63718), Fatemeh Goshadrou (4452061), Nasrin Motamed (2294488), Nasibeh Khayer (4452064)   +3 more
core   +1 more source

Adesão às precauções universais: uma análise do comportamento de equipe de enfermagem

Revista Brasileira de Enfermagem, 1995
A possibilidade de aquisição do vírus de imunodeficiência humana (HIV) por profissionais de saúde tornou mais preocupante a questão dos riscos ocupacionais.
Maria Meimei Brevidelli, Ruth E. Assayag, Gilberto Turcato Jr.   +2 more
doaj   +1 more source

Acidentes de trabalho com trabalhadores de enfermagem Accidentes de trabajo con trabajadores de enfermería Work accidents involving nursing workers

Revista Brasileira de Enfermagem, 2007
O objetivo deste estudo foi o de identificar e analisar acidentes e as cargas de trabalho a que estão expostos os trabalhadores de enfermagem no desenvolvimento de suas atividades.
Emílio José Gonçalves Ribeiro, Helena Eri Shimizu   +1 more
doaj   +1 more source

Evidence for extensive polymorphism of class I genes in the rat major histocompatibility complex (RT1).

, 1983
The major histocompatibility complex of the rat (RT1) has been poorly characterized with respect to the number, linkage, and polymorphism of class I genes.
Wettstein, P. J., Frelinger, J. A., Palmer, M.   +2 more
core   +1 more source

7ème Journée d'études des doctorant·e·s en sociologie des groupes professionnels

APPEL À COMMUNICATIONSUniversité Paris-NanterreJeudi 21 novembre 2024 Pour la septième fois, le RT1 organise sa Journée des doctorant·e·s en sociologie des groupes professionnels. Les doctorant·e·s en sociologie, et plus largement en sciences humaines et
Equipe RT1
core   +1 more source

physical map of the RT1-C/M region of the major histocompatibility complex of the rat

, 2000
The rat is an important model for studying organ graft rejection and susceptibility to certain complex diseases. The MHC, the RT1 complex, plays a decisive role in controlling these traits.
Ioannidu, Sofia
core   +1 more source

Genomic and funtional aspects of the rat MHC, the RT1 complex

, 2001
The major histocompatibility complex (MHC) plays a central role in controlling immune responsiveness, susceptibility to certain diseases and histo-incompatibility, A physical map of the complete rat MHC, the RT1 complex, is presented based on a PAC ...
Gunther, E., Walter, L., Dressel, Ralf
core   +1 more source