Results 11 to 20 of about 85,423 (265)

Cross species extrapolation of the disruption of thyroid hormone synthesis by oxyfluorfen using in vitro data, physiologically based pharmacokinetic (PBPK), and thyroid hormone kinetics models

Current Research in Toxicology, 2023
The thyroid hormones play key roles in physiological processes such as regulation of the metabolic and cardiac systems as well as the development of the brain and surrounding sympathetic nervous system.
Rhylee Decrane, Tammy Stoker, Ashley Murr, Jermaine Ford, Hisham El-Masri   +4 more
doaj   +1 more source

Application of an Accessible Interface for Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation

Frontiers in Pharmacology, 2022
Regulatory toxicology testing has traditionally relied on in vivo methods to inform decision-making. However, scientific, practical, and ethical considerations have led to an increased interest in the use of in vitro and in silico methods to fill data ...
David E. Hines, Shannon Bell, Xiaoqing Chang, Kamel Mansouri, David Allen, Nicole Kleinstreuer   +5 more
doaj   +1 more source

Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin

BMC Pharmacology and Toxicology, 2021
Background Patients with type 2 diabetes mellitus (T2DM) are characterized by an elevated glycemic index and are at a higher risk for complications such as cardiovascular disease, nephropathy, retinopathy and peripheral neuropathy.
Robert Dobbins, Elizabeth K. Hussey, Robin O’Connor-Semmes, Susan Andrews, Wenli Tao, William O. Wilkison, Bentley Cheatham, Katare Sagar, Barkate Hanmant   +8 more
doaj   +1 more source

Organo-Silica Membrane Prepared from TEOS-TEVS Modified with Organic-Acid Catalyst for Brackish Water Desalination

Jurnal Rekayasa Kimia & Lingkungan, 2021
The sol gel process is one of the processes used in the manufacture of thin films on membranes because it can control the pore size in the resulting silica matrix.
Muthia Elma, Aptar Eka Lestari, Anna Sumardi, Zaini Lambri Assyaifi, Adi Darmawan, Dwi Rasy Mujiyanti, Isna Syauqiah, Aulia Rahma, Linda Suciwati, Yanti Mawaddah   +9 more
doaj   +1 more source

Incidence and survival of skin melanoma in Puglia: A comparison with the rest of Italy [PDF]

Journal of Health and Social Sciences, 2016
Introduction: There is a wide heterogeneity in incidence, prevalence, mortality and survival of skin melanoma through the world and in Italy as well. In this study we investigated, for the first time, incidence, mortality and survival of skin melanoma in
Anna Maria Nannavecchia, Danila Bruno, Antonino Ardizzone, Enrico Caputo, Anna Melcarne, Antonia Mincuzzi, Fernando Palma, Lucia Bisceglia, Ida Galise, Francesco Cuccaro   +9 more
doaj   +1 more source

Lisboa, 1975. A correspondência da Embaixada alemã sobre o refúgio concedido a quatro oficiais golpistas

Estudos do Século XX, 2021
Os oficiais golpistas derrotados em 11 de março de 1975 foram em parte afastados dos seus cargos, em parte detidos ou, em menor número, refugiaram-se na vizinha Espanha.
António Louçã
doaj   +1 more source

Formation Process and Properties of Ohmic Contacts Containing Molybdenum to AlGaN/GaN Heterostructures

Advances in Electrical and Electronic Engineering, 2016
Properties of wide bandgap semiconductors as chemical inertness to harsh conditions and possibility of working at high temperature ensure possible applications in the field as military, aerospace, automotive, engine monitoring, flame detection and solar ...
Wojciech Macherzynski, Jacek Gryglewicz, Andrzej Stafiniak, Joanna Prazmowska, Regina Paszkiewicz   +4 more
doaj   +1 more source

Assessing The Innovation Environment Of The Research Triangle Region

Revista de Administração, Sociedade e Inovação, 2020
The paper studies the Research Triangle Region (RTR), an economic development area in the state of North Carolina, USA. RTR comprises two major technological parks: the Research Triangle Park and the Centennial Campus of North Carolina State University ...
Marcelo Goncalves do Amaral, Adriana Ferreira de Faria, Marília Medeiros Schocair   +2 more
doaj   +1 more source

Developmental Neurotoxicity of 3,3',4,4'-Tetrachloroazobenzene with Thyroxine Deficit: Sensitivity of Glia and Dentate Granule Neurons in the Absence of Behavioral Changes

Toxics, 2014
Thyroid hormones (TH) regulate biological processes implicated in neurodevelopmental disorders and can be altered with environmental exposures. Developmental exposure to the dioxin-like compound, 3,3',4,4'-tetrachloroazobenzene (TCAB), induced a dose ...
G. Jean Harry, Michelle J. Hooth, Molly Vallant, Mamta Behl, Gregory S. Travlos, James L. Howard, Catherine J. Price, Sandra McBride, Ron Mervis, Peter R. Mouton   +9 more
doaj   +1 more source

Improving VoIP Bandwidth Utilization Using the PldE Technique

Transport and Telecommunication, 2023
The use of Voice over Internet Protocol (VoIP) innovation is rising due to its various merits. Nevertheless, the ineffective use of bandwidth is a key dilemma that restricts the fast-rising use of VoIP innovation.
Abualhaj Mosleh M., Abu-Shareha Ahmad A., Al-Khatib Sumaya N., Al-Zyoud Mahran, Al Saaidah Adeeb, Hiari Mohammad O., Alsharaiah Mohammad A.   +6 more
doaj   +1 more source