Results 41 to 50 of about 41,206 (299)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Àlvaro Siza and the Fragmented City [PDF]
Athens Journal of Architecture, 2015 In Álvaro Siza’s work, between 1970 and 1980, the presence of the ruin results from his quest for a methodology that allows the inclusion of the city’s past and its remains as an important starting point to embrace reality in its broadest sense.
Carlos Machado
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Image of Wreck and Ruin exhibition opening
This is an image of the opening night of the Wreck and Ruin exhibtion at Falmouth Art Gallery.
Sharp, Leo
core +7 more sources
Stocktaking methods of facilities in a state of ruin
Budownictwo i Architektura, 2019 The stocktaking is the basic form of presenting and protecting the object of the historic ruin. It also allows to monitor the behavior state and the degradation progress of an object.
Katarzyna Drobek +2 more
doaj +1 more source
Displacements: Framing (and) Ruins in John Berger’s King and Indra Sinha’s Animal’s People
Open Library of Humanities, 2021 This essay brings John Berger’s King (1999) together with Indra Sinha’s Animal’s People (2007) to think through displacements with/in ruins. I interpret the settings of the novels, consider the narrative voices used to articulate the stories, and ...
Kylie Crane
doaj +2 more sources
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Inequalities for the ruin probability in a controlled discrete-time risk process [PDF]
, 2009 Ruin probabilities in a controlled discrete-time risk process with a Markov chain interest are studied. To reduce the risk there is a possibility to reinsure a part or the whole reserve. Recursive and integral equations for ruin probabilities are given.
Romera, Rosario, Diasparra, Maikol
core +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source