Results 131 to 140 of about 23,977,071 (291)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Efficient Contactless Palmprint Recognition System Based on Deep Rule-Based Classification

Acta Informatica Pragensia
In recent years, as technology has advanced and more and more activities have become digitized, cybersecurity has become a top priority for governments around the world.
Yacine Belhocine, Abdallah Meraoumia, Khediri Abderrazak, Mohammed Saigaa   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Application of the Sugeno integral in Fuzzy Rule-Based Classification

Applied Soft Computing
The authors would like to thank CNPq (proc. 304118/2023-0, 407206/2023-0, 305805/2021-5, 301618/2019-4), FAPERGS (proc. 19/2551-0001660-3, 24/2551-0001396-2), FAPERGS/CNPq (23/2551-0001865-9, 23/2551-0000126-8), Navarra de Servicios y Tecnologías, S.A. (NASERTIC), Grant Santander-UPNA 2021-2022, and PID2022-136627NB-I00 financiado por MCIN/AEI/10.13039/
Jonata C. Wieczynski, Giancarlo Lucca, Eduardo N. Borges, Asier Urio-Larrea, Carlos Lopez-Molina, Humberto Bustince, Graçaliz Pereira Dimuro   +6 more
openaire   +3 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Classification rule mining based on ant colony optimization algorithm

, 2006
Classification rule mining is an important function of data mining, and is applied in many data analysis tasks. The classification rule mining algorithm based-on ant colony optimization (ACO) is researched in this paper. Some improvements are implemented
Zhu YL(朱云龙), Hu KY(胡琨元), Jin P(金鹏), Li SF(李素粉)   +3 more
core  

A heuristic method for discovering multi-class classification rules from multi-source data in cloud–edge system

Journal of King Saud University: Computer and Information Sciences
The integration of diverse devices has made the establishment of multi-class classification models for multi-source data a primary concern for data mining in cloud–edge system.
Jing Shang, Zhiwen Xiao, Tao Tao, Jibin Wang, Zhihui Wu   +4 more
doaj   +1 more source