An architecture for rule based system explanation [PDF]
A system architecture is presented which incorporate both graphics and text into explanations provided by rule based expert systems. This architecture facilitates explanation of the knowledge base content, the control strategies employed by the system ...
Fennel, T. R., Johannes, James D.
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Adaptive Intelligent Sensing Control Method for Traffic Lights under Real-Time Vehicle Conditions Based on Logic Rules [PDF]
Yang Liu +6 more
openalex +1 more source
Drug Delivery: Drug‐Controlled Release Based on Complementary Base Pairing Rules for Photodynamic–Photothermal Synergistic Tumor Treatment (Small 3/2019) [PDF]
, 2019 Qichen Zhan +4 more
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
RuleR: Improving LLM Controllability by Rule-based Data Recycling [PDF]
Ming Li +5 more
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Design, Operation, and Performance Assessment of Wind Energy-Based Hydrogen Production System with a Novel Rule-Based Control Strategy [PDF]
Sunwoo Kim, Joungho Park, Jay H. Lee
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Simplified rule-based strategy control for electric propulsion system
, 2021 SeongWan Kim +2 more
openalex +1 more source