Results 41 to 50 of about 42,044 (262)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Political fact-checking in the Middle East: What news can be verified in the Arab world?
Open Information Science, 2021 This study examines the news selection processes followed by fact-checking organizations in the Middle East, specifically Egypt, Jordan, and the United Arab Emirates, and gatekeeping such organizations face while working under authoritarian rule.
Fakida Abdelrahman
doaj +1 more source
Sensors, 2022 Autonomous components within electric power systems can be successfully specified by interpreted Petri nets. Such a formal specification makes it possible to check some basic properties of the models, such as determinism or deadlock freedom.
Iwona Grobelna, Paweł Szcześniak
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Journal of Intelligent Systems, 2018 Challenging searching mechanisms are required to cater to the needs of search engine users in probing the voluminous web database. Searching the query matching keyword based on a probabilistic approach is attractive in most of the application areas, viz.
Priya M., Kalpana R.
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Generative AI for Education in Infrastructure Systems: Lessons from a BIM-Based Rule-Checking
ComputersThis study investigates the educational potential of Large Language Models (LLMs) for automating rule-checking tasks in Building Information Modeling (BIM) instruction.
Islem Sahraoui +4 more
doaj +1 more source