Results 161 to 170 of about 1,814,064 (316)

Targeting versus instrument rules for monetary policy [PDF]

open access: yes
Svensson (2003) argues strongly that specific targeting rules-first-order optimality conditions for a specific objective function and model-are normatively superior to instrument rules for the conduct of monetary policy. That argument is based largely on
Bennett T. McCallum, Edward Nelson
core  

Extracting Interpretable Hierarchical Rules from Deep Neural Networks’ Latent Space

open access: yes
238253Deep neural networks, known for their superior learning capabilities, excel in identifying complex relationships between inputs and outputs, leveraging hierarchical, distributed data processing.
Wang, Ya, Paschke, Adrian
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Rules of thumb for chemical engineers /

open access: yes, 2012
The most complete guide of its kind, this is the favored handbook for chemical and process engineers who need a reliable and authoritative solution to their practical on the job problems.
Hall, Stephen(Stephen M.)
core  

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Estimated, Calibrated, and Optimal Interest Rate Rules [PDF]

open access: yes
Estimated, calibrated, and optimal interest rate rules are examined for their ability to dampen economic fluctuations caused by random shocks. A tax rate rule is also considered. The results show that the estimated interest rate rule used in the paper is
Ray C. Fair
core  

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