Results 161 to 170 of about 311,030 (313)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Reevaluating the assessment of nonverbal behavior in psychosis symptomatology: A call for cultural sensitivity. [PDF]

Schizophr Res
Schuch JM, Pratt DN, Haase CM, Qu Y, Mittal VA.   +4 more
europepmc   +1 more source

Indiana Rules of Evidence

Indiana Law Review, 1994
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Utilizing large language models and natural language processing to classify ischemia status from cardiac stress tests in a large multicenter healthcare system. [PDF]

BMC Res Notes
Cave S, Peterson KS, Plomondon ME, Waldo SW.   +3 more
europepmc   +1 more source

Evidence without Rules

, 2018
Bennett Capers
openalex   +1 more source

Responses of Firms to Tax, Administrative and Accounting Rules: Evidence from Armenia

, 2017
Zareh Asatryan, Andreas Peichl
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

The People versus Behavioral Science: Alignment between lay and scientific understanding of compliance. [PDF]

PLoS One
Reinders Folmer CP, Kuiper ME, van Rooij B.   +2 more
europepmc   +1 more source

The effect of conventional and unconventional monetary policy rules on inflation expectations: theory and evidence

, 2012
Roger E. A. Farmer
openalex   +1 more source